Global Patent Index - EP 0833663 A4

EP 0833663 A4 19990407 - CARBOHYDRATE-MEDIATED COUPLING OF PEPTIDES TO IMMUNOGLOBULINS

Title (en)

CARBOHYDRATE-MEDIATED COUPLING OF PEPTIDES TO IMMUNOGLOBULINS

Title (de)

KARBOHYDRATMEDIIERTE KUPPELUNG VON PEPTIDEN AN IMMUNGLOBULINEN

Title (fr)

COUPLAGE DE PEPTIDES A DES IMMUNOGLOBULINES PAR L'INTERMEDIAIRE DE GLUCIDES

Publication

EP 0833663 A4 19990407 (EN)

Application

EP 96916458 A 19960513

Priority

  • US 9606756 W 19960513
  • US 44132895 A 19950515
  • US 47742495 A 19950607

Abstract (en)

[origin: WO9636357A1] The present invention relates to methods for enzymatically coupling peptides to immunoglobulin molecules via carbohydrate residues of immunoglobulin molecules, and to immunoglobulin-carbohydrate-linked peptide ("ICLP") conjugates produced by such methods. ICLP conjugates have been found to be superior in eliciting an immune response when compared to unconjugated peptide.

IPC 1-7

A61K 39/395; A61K 39/40; A61K 39/42; A61K 39/44; A61K 39/385; C07K 16/00; C12P 21/08

IPC 8 full level

A61K 38/47 (2006.01); A61K 39/145 (2006.01); A61K 39/385 (2006.01); A61K 47/48 (2006.01); C07K 14/11 (2006.01); C07K 16/32 (2006.01); C12P 21/08 (2006.01)

CPC (source: EP)

A61K 38/47 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 39/385 (2013.01); A61K 47/68 (2017.07); A61K 47/6811 (2017.07); A61K 47/6889 (2017.07); C07K 14/005 (2013.01); C07K 16/32 (2013.01); A61K 2039/6056 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01)

Citation (search report)

  • [X] EP 0088695 A2 19830914 - CYTOGEN CORP [US]
  • [Y] EP 0326322 A1 19890802 - LILLY CO ELI [US]
  • [PX] BRUMEANU, T.-D. ET AL: "Enzymically mediated, glycosidic conjugation of immunoglobulins with viral epitopes", J. IMMUNOL. METHODS (1995), 183(2), 185-97 CODEN: JIMMBG;ISSN: 0022-1759, XP004021011
  • [YD] MITCHELL R N ET AL: "THE USE OF RADIOACTIVE CYSTEINE METHYL ESTER FOR LABELING GLYCOSYLATED MOLECULES OXIDIZED BY PER IODATE OR NEURAMINIDASE PLUS GALACTOSE OXIDASE.", ARCH BIOCHEM BIOPHYS 229 (2). 1984. 544-554. CODEN: ABBIA4 ISSN: 0003-9861, XP002088227
  • [Y] O'SHANESSY D J ET AL: "Specific conjugation reactions of the oligosaccharide moieties of immunoglobulins", J. APPL. BIOCHEM., vol. 7, no. 4-5, 1985, pages 347-355, XP002088228
  • [Y] SOLCIA E ET AL: "Cathepsin E in antigen-presenting Langerhans and interdigitating reticulum cells. Its possible role in antigen processing", EUR. J. HISTOCHEM., vol. 37, no. 1, - 1993, pages 19 - 26, XP002088229
  • [YD] YONEZAWA, SATOSHI ET AL: "Cathepsin E from rat neutrophils: its properties and possible relations to cathepsin D-like and cathepsin E -like acid proteinases", ARCH. BIOCHEM. BIOPHYS. (1987), 256(2), 499-508 CODEN: ABBIA4;ISSN: 0003-9861, XP002088230
  • [YD] CABACUNGAN J C ET AL: "Amine boranes as alternative reducing agents for reductive alkylation of proteins", ANAL. BIOCHEM., vol. 124, no. 2, - 1982, pages 272 - 278, XP002084857
  • [A] BRUMEANU T D ET AL: "Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus.", JOURNAL OF EXPERIMENTAL MEDICINE 178 (5). 1993. 1795-1799. ISSN: 0022-1007, XP000567066
  • [T] BRUMEANU T-D ET AL: "Presentation of a viral peptide assembled on the carbohydrate moieties of immunoglobulin does not require processing.", EUROPEAN JOURNAL OF IMMUNOLOGY 27 (9). 1997. 2408-2416. ISSN: 0014-2980, XP002088231
  • See references of WO 9636357A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9636357 A1 19961121; AU 5920096 A 19961129; CA 2227326 A1 19961121; EP 0833663 A1 19980408; EP 0833663 A4 19990407

DOCDB simple family (application)

US 9606756 W 19960513; AU 5920096 A 19960513; CA 2227326 A 19960513; EP 96916458 A 19960513