EP 0833667 A1 19980408 - STABILIZATION OF POLYNUCLEOTIDE COMPLEXES
Title (en)
STABILIZATION OF POLYNUCLEOTIDE COMPLEXES
Title (de)
STABILISIERUNG VON POLYNUKLEOTIDKOMPLEXEN
Title (fr)
STABILISATION DE COMPLEXES DE POLYNUCLEOTIDES
Publication
Application
Priority
- US 9607866 W 19960528
- US 48543095 A 19950607
Abstract (en)
[origin: WO9640265A1] Polynucleotide complexes are stabilized by adding a cryoprotectant compound and lyophilizing the resulting formulation. Cryoprotectant compounds comprise carbohydrates, preferably lactose and sucrose, but also glucose, maltodextrins, mannitol, sorbitol, trehalose, and others. Betaines prolines, and other amino acids may also be useful. Preferably, DNA complexes are cryoprotected with lactose at concentrations of about 1.25 % to about 10 % (w/vol). Conventional buffers may also be added to the mixture. The lyophilized formulations may be stored for extended periods of time and then rehydrated prior to use.
IPC 1-7
IPC 8 full level
C12Q 1/68 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61K 47/26 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07H 21/00 (2006.01)
CPC (source: EP)
A61K 9/0075 (2013.01); A61K 9/1272 (2013.01); A61K 47/26 (2013.01); A61K 47/54 (2017.07); A61K 47/543 (2017.07); A61K 47/544 (2017.07); A61K 47/554 (2017.07); A61K 47/6911 (2017.07); A61K 47/6929 (2017.07); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9640265 A1 19961219; AU 5938196 A 19961230; AU 707734 B2 19990715; CA 2223921 A1 19961219; EP 0833667 A1 19980408; EP 0833667 A4 20011121; EP 1491217 A1 20041229; JP 2001516329 A 20010925
DOCDB simple family (application)
US 9607866 W 19960528; AU 5938196 A 19960528; CA 2223921 A 19960528; EP 04000585 A 19960528; EP 96916714 A 19960528; JP 50079397 A 19960528