EP 0833822 A1 19980408 - 4-PHENYLAMINOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES
Title (en)
4-PHENYLAMINOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES
Title (de)
4-PHENYLAMINOTHIAZOLEDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSTELLUNGEN DIE SIE ENTHALTEN
Title (fr)
DERIVES DE 4-PHENYLAMINOTHIAZOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
Publication
Application
Priority
- FR 9600941 W 19960618
- FR 9507437 A 19950621
Abstract (en)
[origin: US5880135A] PCT No. PCT/FR96/00941 Sec. 371 Date Dec. 22, 1997 Sec. 102(e) Date Dec. 22, 1997 PCT Filed Jun. 18, 1996 PCT Pub. No. WO97/00868 PCT Pub. Date Jan. 9, 1997A compound, as well as its stereoisomers and addition salts, possssing antagonist activity with respect to corticotropin releasing hormone (CRF) has the formula: <IMAGE> in which R1, and R21 which are identical or different, are independently selected from a halogen atom; a (C1-C5)hydroxyalkyl radical; a (C1-C5)alkyl; a (C7-C10)aralkyl; a (C1-C5)alkoxy; a trifluoromethyl; a nitro; a nitrile; an -SR group in which R is selected from hydrogen, a (C1-C5)alkyl radical and a (C7-C10)aralkyl radical; an -S-CO-R group in which R is selected from a (C1-C5)alkyl radical and an aralkyl radical in which the aryl part is (C6-C8) and the alkyl part is (C1-C4); a -COOR' group in which R' is selected from hydrogen and a (C1-C5)alkyl; a -CONR-R'R'' group with R' and R'' as defined above for R'; an -NR'R'' group with R' and R'' as defined above for R'; a -CONRaRb or -NRaRb group in which Ra and Rb constitute, with the nitrogen atom to which they are bonded, a 5- to 7-membered heterocycle; and an -NHCO-NR'R'' group with R' and R'' as defined above for R'; R3 represents hydrogen or is as defined above for R1 and R2; R4 is selected from a hydrogen atom; a (C1-C5)alkyl; a halogen, a hydroxymethyl group; and a formyl group; R5 is selected from a (C1-C5)alkyl; a (C3-C7)cycloalkyl group; a cycloalkylalkyl group in which the cycloalkyl part is (C3-C7) and the alkyl part is (C1-C5); and alkenyl containing 5 to 6 carbon atoms; n represents zero or one; R6 is selected from a (C1-C5)alkyl; an alkoxyalkyl in which the alkyl parts are (C1-C5); a (C3-C7)cycloalkyl; a cycloalkylalkyl group in which the cycloalkyl part is (C3-C7) and the alkyl part is (C1-C5); a cycloalkyloxyalkyl radical in which the cycloalkyl is (C3-C7) and the alkyl part is (C1-C4); a hydroxyalkyloxyalkyl radical in which the alkyls are (C2-C10); and an alkoxyalkyloxyalkyl radical in which the alkyls are (C3-C12); Z represents an optionally substituted bi- or tricyclic aromatic or heteroaromatic group.
IPC 1-7
IPC 8 full level
A61K 31/425 (2006.01); A61K 31/426 (2006.01); C07D 277/20 (2006.01); A61K 31/427 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/498 (2006.01); A61K 31/50 (2006.01); A61K 31/505 (2006.01); A61K 31/517 (2006.01); A61K 31/535 (2006.01); A61P 5/00 (2006.01); A61P 5/04 (2006.01); C07D 277/42 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR US)
A61P 3/00 (2018.01 - EP); A61P 5/00 (2018.01 - EP); A61P 5/04 (2018.01 - EP); A61P 15/00 (2018.01 - EP); C07D 277/42 (2013.01 - EP KR US); C07D 417/12 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
US 5880135 A 19990309; AU 6362796 A 19970122; AU 710300 B2 19990916; BR 9609420 A 19990518; CA 2222266 A1 19970109; CZ 410397 A3 19980415; EE 9700333 A 19980615; EP 0833822 A1 19980408; FR 2735777 A1 19961227; FR 2735777 B1 19970912; HU P9900056 A2 19990528; IL 122293 A0 19980405; IS 4635 A 19971216; JP 3067807 B2 20000724; JP H10511693 A 19981110; KR 19990028325 A 19990415; MX 9710378 A 19980731; NO 975987 D0 19971219; NO 975987 L 19980219; NZ 312157 A 19990429; PL 324202 A1 19980511; RU 2146253 C1 20000310; SK 171197 A3 19980805; TR 199701654 T1 19980521; TW 416952 B 20010101; WO 9700868 A1 19970109; ZA 965294 B 19971222
DOCDB simple family (application)
US 94509897 A 19971222; AU 6362796 A 19960618; BR 9609420 A 19960618; CA 2222266 A 19960618; CZ 410397 A 19960618; EE 9700333 A 19960618; EP 96922946 A 19960618; FR 9507437 A 19950621; FR 9600941 W 19960618; HU P9900056 A 19960618; IL 12229396 A 19960618; IS 4635 A 19971216; JP 50361697 A 19960618; KR 19970709640 A 19971220; MX 9710378 A 19971218; NO 975987 A 19971219; NZ 31215796 A 19960618; PL 32420296 A 19960618; RU 98100764 A 19960618; SK 171197 A 19960618; TR 9701654 T 19960618; TW 85107427 A 19960717; ZA 965294 A 19960621