EP 0833823 A1 19980408 - CERTAIN SUBSTITUTED BENZYLAMINE DERIVATIVES: A NEW CLASS OF NEUROPEPTIDE Y1 SPECIFIC LIGANDS
Title (en)
CERTAIN SUBSTITUTED BENZYLAMINE DERIVATIVES: A NEW CLASS OF NEUROPEPTIDE Y1 SPECIFIC LIGANDS
Title (de)
BESTIMMTE SUBSTITUIERTE BENZYLAMINDERIVATE; EINE NEUE KLASSE VON NEUROPEPTID Y1 SPEZIFISCHEN LIGANDEN
Title (fr)
DERIVES DE BENZYLAMINE SUBSTITUES PARTICULIERS; UNE NOUVELLE CLASSE DE LIGANDS SPECIFIQUES DES NEUROPEPTIDES Y1
Publication
Application
Priority
- US 9605843 W 19960426
- US 47838395 A 19950607
- US 48497495 A 19950607
- US 9514472 W 19951107
Abstract (en)
[origin: WO9640660A1] This invention encompasses compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein Ar is an aryl group preferably selected from the group consisting of phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2-, 4- or 5-pyrimidyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, lower alkoxy, or lower alkyl; B is sulfur, oxygen, N(R5) or C(R5)(R6); or B represents a group of formula (II) optionally substituted with halogen, hydroxy, lower alkyl or lower alkoxy; n is 1, 2, or 3; m is 2, 3, or 4; W, X, Y, and T are the same or different and represent hydrogen, halogen, hydroxy, lower alkoxy, or lower alkoxy alkoxy; R1 and R2 are the same or different and represent hydrogen, or lower alkyl; R3 and R4 are the same or different and represent hydrogen, lower alkyl, or lower alkoxy; R5 represents lower alkyl, phenyl, 2-, 3-, or 4-pyridyl, phenyl, lower alkyl, or 2-, 3-, or 4-pyridyl, lower alkyl; and A and R6 are the same or different and represent hydrogen, hydroxyl, amino, lower alkyl, lower alkoxy, phenyl, optionally substituted benzyloxy, 2-, 3-, or 4-pyridyl, phenoxy, 2-, 3-, or 4-pyridyloxy, or -(CH2)p-A'-(CH2)q-B' where p is 0-5, q is 1-5, and A' is a direct bond, oxygen or sulfur, and B' is hydrogen, lower alkyl, lower alkoxy, phenyl, 2-, 3-, or 4-pyridyl, phenoxy, 2-, 3-, or 4-pyridyloxy, carboxyl, carboalkoxy, carboxamido, mono- or dialkylcarboxamido, amino, or mono- or dialkylamino.
IPC 1-7
C07D 295/08; A61K 31/495; C07D 317/58; A61K 31/505; C07D 295/02; C07D 239/42; C07D 213/74
IPC 8 full level
C07D 295/02 (2006.01); A61K 31/38 (2006.01); A61K 31/382 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/495 (2006.01); A61K 31/505 (2006.01); A61K 31/55 (2006.01); A61P 1/00 (2006.01); A61P 3/04 (2006.01); A61P 9/12 (2006.01); C07D 213/38 (2006.01); C07D 213/74 (2006.01); C07D 223/08 (2006.01); C07D 233/00 (2006.01); C07D 239/00 (2006.01); C07D 239/42 (2006.01); C07D 241/04 (2006.01); C07D 295/08 (2006.01); C07D 295/096 (2006.01); C07D 307/22 (2006.01); C07D 309/14 (2006.01); C07D 317/58 (2006.01); C07D 333/36 (2006.01); C07D 335/02 (2006.01); C07D 337/04 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01)
IPC 8 main group level
C07D (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 3/04 (2017.12); A61P 9/12 (2017.12); C07D 213/38 (2013.01); C07D 239/42 (2013.01); C07D 295/096 (2013.01); C07D 309/14 (2013.01); C07D 317/58 (2013.01); C07D 335/02 (2013.01)
Citation (search report)
See references of WO 9640660A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9640660 A1 19961219; AU 5578796 A 19961230; BR 9609334 A 19990525; CA 2220958 A1 19961219; CO 4700426 A1 19981229; EP 0833823 A1 19980408; IL 117997 A0 19961031; JP H10507203 A 19980714; MA 23860 A1 19961231; MX 9709980 A 19980329; PE 34297 A1 19970924; TR 199600382 A2 19961221
DOCDB simple family (application)
US 9605843 W 19960426; AU 5578796 A 19960426; BR 9609334 A 19960426; CA 2220958 A 19960426; CO 96022963 A 19960508; EP 96913198 A 19960426; IL 11799796 A 19960422; JP 50049097 A 19960426; MA 24226 A 19960508; MX 9709980 A 19960426; PE 00032596 A 19960508; TR 9600382 A 19960510