EP 0835104 A4 19991020 - USE OF STAT 5 SH2 DOMAIN SPECIFIC COMPOUNDS TO ENHANCE ERYTHROPOIESIS

Title (en)

USE OF STAT 5 SH2 DOMAIN SPECIFIC COMPOUNDS TO ENHANCE ERYTHROPOIESIS

Title (de)

VERWENDUNG VON STAT 5 SH2 DOMAINE SPEZIFISCHER VERBINDUNGEN ZUR FÖRDERUNG DER ERYTHROPOESE

Title (fr)

UTILISATION DE COMPOSES SE LIANT SPECIFIQUEMENT AU DOMAINE STAT 5 SH2 POUR AUGMENTER L'ERYTHROPOIESE

Publication

EP 0835104 A4 19991020 (EN)

Application

EP 96923579 A 19960628

Priority

US 9611158 W 19960628
US 49735795 A 19950630
US 59871596 A 19960208

Abstract (en)

[origin: WO9702024A1] Invented is a method of enhancing erythropoiesis in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human Stat 5 SH2 domain with a binding affinity greater than fifty-fold higher than the binding affinity with which the compound binds to a human Stat 6 SH2 domain, binds to a human hcp SH2 domain, a human Grb2 SH2 domain, a human SH-PTP2 SH2 domain and a human p85 SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such Stat 5 SH2 domain, and binds to a human src SH2 domain, a human lck SH2 domain and a human fyn SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such Stat 5 SH2 domain.

IPC 1-7

A61K 31/00; G01N 33/53

IPC 8 full level

C07D 207/50 (2006.01); A61K 31/12 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/192 (2006.01); A61K 31/195 (2006.01); A61K 31/40 (2006.01); A61K 31/435 (2006.01); A61K 31/437 (2006.01); A61K 31/50 (2006.01); A61K 31/546 (2006.01); A61K 45/00 (2006.01); A61P 7/06 (2006.01); C07D 495/14 (2006.01); C07D 495/22 (2006.01); C07D 501/36 (2006.01); C07K 14/47 (2006.01)

CPC (source: EP)

A61K 31/12 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/192 (2013.01); A61K 31/40 (2013.01); A61K 31/437 (2013.01); A61K 31/50 (2013.01); A61K 31/546 (2013.01); A61P 7/06 (2017.12); C07K 14/47 (2013.01); C07K 2319/00 (2013.01); C12N 2799/026 (2013.01)

Citation (search report)

[PX] WO 9525118 A2 19950921 - TRUSTEES OF TUFTS UNIVERSITY [US]
[E] EP 0728482 A2 19960828 - SMITHKLINE BEECHAM CORP [US]
[A] GB 2171303 A 19860828 - CHUGAI PHARMACEUTICAL CO LTD
[A] US 4987121 A 19910122 - BAERTSCHI ALEX J [US], et al
[A] US 4482571 A 19841113 - ABRAHAM DONALD J [US]
[A] US 5366996 A 19941122 - ELFORD HOWARD L [US], et al
See references of WO 9702024A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

DOCDB simple family (publication)

WO 9702024 A1 19970123; AU 6405596 A 19970205; CA 2225666 A1 19970123; EP 0835104 A1 19980415; EP 0835104 A4 19991020; JP H10512585 A 19981202

DOCDB simple family (application)

US 9611158 W 19960628; AU 6405596 A 19960628; CA 2225666 A 19960628; EP 96923579 A 19960628; JP 50526897 A 19960628