Global Patent Index - EP 0836383 A1

EP 0836383 A1 19980422 - COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

KOMBINATIONEN VON INHIBITOREN VON FARNESYL PROTEIN TRANSFERASE

Title (fr)

COMBINAISONS D'INHIBITEURS DE FARNESYL-PROTEINE TRANSFERASE

Publication

EP 0836383 A1 19980422 (EN)

Application

EP 96923503 A 19960626

Priority

  • GB 9603091 A 19960214
  • US 9611022 W 19960626
  • US 225195 P 19950629

Abstract (en)

[origin: WO9701275A1] The present invention relates to compositions comprising amounts of at least two therapeutic agents selected from a group consisting of a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is competitive with respect to the protein substrate of the enzyme and a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is competitive with respect to farnesyl pyrophosphate. Further contained in this invention are methods of inhibiting farnesyl-protein transferase and treating cancer in a mammal, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is a competitive inhibitor with respect to the protein substrate of the enzyme and a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is a competitive inhibitor with respect to farnesyl pyrophosphate, in amounts sufficient to achieve an additive or synergistic therapeutic effect. The invention also relates to methods of preparing such compositions.

IPC 1-7

A01N 37/18; A01N 43/40; A61K 31/445; A61K 38/00

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/20 (2006.01); A61K 31/202 (2006.01); A61K 31/22 (2006.01); A61K 31/223 (2006.01); A61K 31/255 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/425 (2006.01); A61K 31/428 (2006.01); A61K 31/495 (2006.01); A61K 31/66 (2006.01); A61K 31/662 (2006.01); A61K 31/664 (2006.01); A61K 38/03 (2006.01); A61K 38/55 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP)

A61K 38/03 (2013.01); A61K 38/55 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)

C-Set (source: EP)

  1. A61K 38/55 + A61K 38/55
  2. A61K 38/03 + A61K 38/03
  3. A61K 38/03 + A61K 2300/00
  4. A61K 38/55 + A61K 2300/00

Citation (search report)

See references of WO 9701275A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9701275 A1 19970116; AU 6399696 A 19970130; AU 714072 B2 19991216; CA 2225255 A1 19970116; EP 0836383 A1 19980422; JP 2000501063 A 20000202

DOCDB simple family (application)

US 9611022 W 19960626; AU 6399696 A 19960626; CA 2225255 A 19960626; EP 96923503 A 19960626; JP 50457397 A 19960626