EP 0836383 A1 19980422 - COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Title (en)
COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Title (de)
KOMBINATIONEN VON INHIBITOREN VON FARNESYL PROTEIN TRANSFERASE
Title (fr)
COMBINAISONS D'INHIBITEURS DE FARNESYL-PROTEINE TRANSFERASE
Publication
Application
Priority
- GB 9603091 A 19960214
- US 9611022 W 19960626
- US 225195 P 19950629
Abstract (en)
[origin: WO9701275A1] The present invention relates to compositions comprising amounts of at least two therapeutic agents selected from a group consisting of a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is competitive with respect to the protein substrate of the enzyme and a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is competitive with respect to farnesyl pyrophosphate. Further contained in this invention are methods of inhibiting farnesyl-protein transferase and treating cancer in a mammal, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is a competitive inhibitor with respect to the protein substrate of the enzyme and a farnesyl protein transferase inhibitor which is an effective inhibitor of the enzyme because it is a competitive inhibitor with respect to farnesyl pyrophosphate, in amounts sufficient to achieve an additive or synergistic therapeutic effect. The invention also relates to methods of preparing such compositions.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/20 (2006.01); A61K 31/202 (2006.01); A61K 31/22 (2006.01); A61K 31/223 (2006.01); A61K 31/255 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/425 (2006.01); A61K 31/428 (2006.01); A61K 31/495 (2006.01); A61K 31/66 (2006.01); A61K 31/662 (2006.01); A61K 31/664 (2006.01); A61K 38/03 (2006.01); A61K 38/55 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 38/03 (2013.01); A61K 38/55 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
See references of WO 9701275A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9701275 A1 19970116; AU 6399696 A 19970130; AU 714072 B2 19991216; CA 2225255 A1 19970116; EP 0836383 A1 19980422; JP 2000501063 A 20000202
DOCDB simple family (application)
US 9611022 W 19960626; AU 6399696 A 19960626; CA 2225255 A 19960626; EP 96923503 A 19960626; JP 50457397 A 19960626