EP 0836617 A1 19980422 - PAREVINS AND TACHYTEGRINS
Title (en)
PAREVINS AND TACHYTEGRINS
Title (de)
PAREVINE UND TACHYTEPRINE
Title (fr)
PAREVINES ET TACHYTEGRINES
Publication
Application
Priority
- US 9611323 W 19960703
- US 89895 P 19950706
Abstract (en)
[origin: WO9702287A1] Compounds based on the antimicrobial protegrins and tachyplesins are disclosed having a net positive charge of at least +1 at physiological pH, comprising from 15 % to 50 % basic amino acids, and having an amino acid sequence of the formula: A1-A2-A3-C4*-C5*-C6*-A7-C8-A9-A10-A11-A12-C13-A14-C15*-C16*-C17*-A18, within a size range of 11-24 amino acids when the above formula is extended at either the N- or C-terminus by additional, non-interfering, amino acids and wherein the N-terminus may be acylated and the C-terminus may be amidated or esterified and disulfide bridges may be present or absent in a -SH stabilized linear form. In one embodiment, C8 and C13 denote cysteine, homocysteine or penicillamine; C4*-C6* and C15*-C16* denote the preceding or any naturally-occurring amino acid save glutamic acid, aspartic acid and proline, except when either or both of C4* or C17* are optionally absent wherein only proline is excluded at C5* and C15*; A1-A3 and A18 may be present or absent and denote any naturally-occurring amino acid except glutamic acid, aspartic acid, proline and cysteine; A7 and A14 denote a hydrophobic or a small amino acid; A9-A12 must be capable of forming a beta -turn in the compound; and, at least one of A9-A12 must be a basic amino acid.
IPC 1-7
C07K 7/06; C07K 7/08; C07K 14/00; A61K 38/08; A61K 38/10; A61K 38/16; A01N 25/00; C12N 15/11
IPC 8 full level
C12N 15/09 (2006.01); A01N 37/46 (2006.01); A01N 63/00 (2006.01); A61K 38/00 (2006.01); A61L 12/14 (2006.01); A61P 1/02 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); C07K 7/08 (2006.01); C07K 16/00 (2006.01); C12N 1/20 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP)
A01N 37/46 (2013.01); A61L 12/14 (2013.01); A61P 1/02 (2017.12); A61P 31/04 (2017.12); A61P 31/12 (2017.12); C07K 7/08 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9702287 A1 19970123; AU 6452996 A 19970205; AU 714294 B2 19991223; CA 2226121 A1 19970123; EP 0836617 A1 19980422; EP 0836617 A4 20000628; JP H11509842 A 19990831
DOCDB simple family (application)
US 9611323 W 19960703; AU 6452996 A 19960703; CA 2226121 A 19960703; EP 96923662 A 19960703; JP 50530797 A 19960703