Title (en)

NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR

Title (de)

HUMANER AN DAS G-PROTEIN GEKOPPELTER REZEPTOR

Title (fr)

NOUVEAU RECEPTEUR COUPLE A LA PROTEINE G HUMAINE

Publication

EP 0836621 A4 19981014 (EN)

Application

EP 96928190 A 19960814

Priority

• US 9613239 W 19960814
• US 9607622 W 19960520

Abstract (en)

[origin: WO9744360A1] Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

IPC 1-7

C07K 14/705; C07K 16/28; C12N 5/10; C12N 15/12

IPC 8 full level

A61K 31/00 (2006.01); A61K 45/00 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 9/00 (2006.01); A61P 9/02 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/00 (2006.01); A61P 13/08 (2006.01); A61P 19/00 (2006.01); A61P 19/10 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 37/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); G01N 33/567 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 1/00 (2017.12); A61P 1/04 (2017.12); A61P 9/00 (2017.12); A61P 9/02 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/00 (2017.12); A61P 13/08 (2017.12); A61P 19/00 (2017.12); A61P 19/10 (2017.12); A61P 25/18 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 37/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07K 14/70571 (2013.01); C07K 14/715 (2013.01); C07K 14/723 (2013.01); G01N 33/5008 (2013.01); G01N 33/5091 (2013.01); G01N 33/567 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

• [A] WO 9506117 A1 19950302 - SMITHKLINE BEECHAM PLC [GB], et al
• [XD] KAPAS, S. ET AL.: "Cloning and expression of cDNA encoding a rat adrenomedullin receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 43, 27 October 1995 (1995-10-27), pages 25344 - 7, XP002072564
• [X] SAEKI, Y. ET AL.: "Molecular cloning of a novelputative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system.", FEBS LETTERS, vol. 336, no. 2, December 1993 (1993-12-01), pages 317 - 22, XP002072565
• [X] HARRISON, J.K. ET AL.: "Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver.", FEBS LETTERS, vol. 318, no. 1, February 1993 (1993-02-01), pages 17 - 22, XP002072566
• See references of WO 9744360A1

Designated contracting state (EPC)

BE CH DE DK FR GB IT LI NL

DOCDB simple family (publication)

WO 9744360 A1 19971127; AU 5875796 A 19971209; AU 6775496 A 19971209; EP 0836621 A1 19980422; EP 0836621 A4 19981014; JP H11511030 A 19990928; WO 9744359 A1 19971127

DOCDB simple family (application)

US 9613239 W 19960814; AU 5875796 A 19960520; AU 6775496 A 19960814; EP 96928190 A 19960814; JP 52760297 A 19960814; US 9607622 W 19960520