EP 0839154 A1 19980506 - BIOLOGICALLY ACTIVE PEPTIDES AND COMPOSITIONS, THEIR USE
Title (en)
BIOLOGICALLY ACTIVE PEPTIDES AND COMPOSITIONS, THEIR USE
Title (de)
BIOLOGISCH AKTIVE PEPTIDE UND IHRE ZUBEREITUNGEN UND VERWENDUNGEN
Title (fr)
PEPTIDES ET COMPOSITIONS BIOLOGIQUEMENT ACTIFS, ET LEUR UTILISATION
Publication
Application
Priority
- GB 9600942 W 19960422
- GB 9508195 A 19950420
Abstract (en)
[origin: WO9633211A1] Compounds of general formula (I) wherein: R1 and R70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; R2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R6 represents a group -CH= as hereinafter described; R73 represents a hydrogen atom or an optional substituent or is absent when R6 represents a methylene group or a group -CH= as hereinafter described; Y represents an optional substituent; n represents 0, 1, 2, 3, or 4; R3 represents a hydrogen atom, or an optionally substituted alkyl group; R74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group; R7 represents a hydrogen atom or an alkyl group; R75 represents an optionally substituted alkyl group; and i) R6 and R71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R72 represents a hydrogen atom; or ii) R71 represents a hydrogen atom or an optionally substituted alkyl or acyl group and R72 represents a hydrogen atom or R71 and R72 each represent radicals so that a double bond is formed between the carbon atoms to which they are attached; and R6 represents an optionally substituted methylene group bonded to the indole moiety thereby to form a tricyclic moiety; or R6 represents an optionally substituted group -CH= bonded to the indole moiety thereby to form an aromatic tricyclic moiety; for use in therapy and as antimitotic reagents are described. Novel hemiasterlins, criamides and geodiamolides are also described.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 5/02 (2006.01); C07K 5/027 (2006.01); C07K 5/078 (2006.01); C07K 5/08 (2006.01); C07K 5/083 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); C07K 5/0205 (2013.01 - EP US); C07K 5/0827 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9633211A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9633211 A1 19961024; AT E256698 T1 20040115; AU 5341696 A 19961107; CA 2220021 A1 19961024; CA 2220021 C 20120626; DE 69631141 D1 20040129; DE 69631141 T2 20040930; DK 0839154 T3 20040419; EP 0839154 A1 19980506; EP 0839154 B1 20031217; ES 2213173 T3 20040816; GB 9508195 D0 19950607; JP 2007031441 A 20070208; JP 4006466 B2 20071114; JP 4008493 B2 20071114; JP H11505211 A 19990518; PT 839154 E 20040531; US 2005171137 A1 20050804; US 2009088573 A1 20090402; US 6153590 A 20001128; US 6870028 B1 20050322; US 7410951 B2 20080812; US 7772397 B2 20100810
DOCDB simple family (application)
GB 9600942 W 19960422; AT 96910116 T 19960422; AU 5341696 A 19960422; CA 2220021 A 19960422; DE 69631141 T 19960422; DK 96910116 T 19960422; EP 96910116 A 19960422; ES 96910116 T 19960422; GB 9508195 A 19950420; JP 2006221150 A 20060814; JP 53156496 A 19960422; PT 96910116 T 19960422; US 17671608 A 20080721; US 3492205 A 20050114; US 59341700 A 20000614; US 93058498 A 19980202