EP 0840725 A1 19980513 - AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS
Title (en)
AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS
Title (de)
AZETIDINONDERIVATE ZUR BEHANDLUNG VON ATHEROSCLEROSIS
Title (fr)
DERIVES DE L'AZETIDINONE POUR LE TRAITEMENT DE L'ATHEROSCLEROSE
Publication
Application
Priority
- EP 9602765 W 19960620
- GB 9513442 A 19950701
- GB 9515056 A 19950722
- GB 9515206 A 19950725
- GB 9516985 A 19950818
- GB 9525132 A 19951208
- GB 9608650 A 19960426
- GB 9608651 A 19960426
Abstract (en)
[origin: WO9702242A1] Azetidinone compounds of formule (I) in which: R<1> and R<2>, which may be the same or different, is each selected from hydrogen, halogen or C(1-8)alkyl; R<4> and R<5> which may be the same or different is each selected from hydrogen, C(1-6)alkyl, C(2-6)alkenyl, aryl, aryl(C1-4)alkyl and heteroaryl(C1-4)alkyl each of which may be optionally substituted or R<4> and R<5> may be linked together to form the remainder of a (C3-7)cycloalkyl ring; X is a linker group; Y is an optionally substituted aryl group; Z is oxygen and R<3> is C(1-8)alkyl, C(3-8)cycloalkyl, C(3-8)cycloalkylC(1-6)alkyl, heteroaryl, heteroaryl(C1-4)alkyl, aryl, or aryl(C1-4)alkyl, each of which may be optionally substituted or Z is S(O)n in which n is 0, 1 or 2 and R<3> is C(1-8)alkyl, C(3-8)cycloalkyl, C(3-8)cycloalkylC(1-6)alkyl, aryl, aryl(C1-4)alkyl, heteroaryl, or heteroaryl(C1-4)alkyl, each of which may be optionally substituted are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.
IPC 1-7
C07D 205/08; C07D 205/09; C07D 405/12; C07D 401/12; C07D 409/12; C07D 417/12; C07D 405/06; A61K 31/395
IPC 8 full level
A61K 31/397 (2006.01); A61K 31/427 (2006.01); A61K 31/4427 (2006.01); A61P 9/10 (2006.01); C07D 205/08 (2006.01); C07D 205/085 (2006.01); C07D 205/095 (2006.01); C07D 401/12 (2006.01); C07D 205/09 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR)
A61P 9/10 (2018.01 - EP); C07D 205/08 (2013.01 - KR); C07D 205/085 (2013.01 - EP); C07D 205/095 (2013.01 - EP); C07D 401/12 (2013.01 - EP); C07D 405/12 (2013.01 - EP); C07D 409/12 (2013.01 - EP); C07D 417/12 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9702242 A1 19970123; AP 728 A 19990129; AP 9701161 A0 19980131; AU 6305096 A 19970205; AU 708032 B2 19990729; BG 102214 A 19980831; BR 9609445 A 19990406; CA 2225627 A1 19970123; CN 1197452 A 19981028; CZ 422197 A3 19980617; EA 199800109 A1 19981029; EP 0840725 A1 19980513; HU P9901153 A2 19990830; HU P9901153 A3 19991129; IL 122650 A0 19980816; JP 2002515852 A 20020528; KR 19990028630 A 19990415; MA 23922 A1 19961231; MX 9800186 A 19980731; NO 976158 D0 19971230; NO 976158 L 19980225; NZ 311684 A 20000428; OA 10648 A 20020925; PE 8998 A1 19980320; PL 324240 A1 19980511; SK 178497 A3 19980708; TR 199701762 T1 19980521
DOCDB simple family (application)
EP 9602765 W 19960620; AP 9701161 A 19960620; AU 6305096 A 19960620; BG 10221498 A 19980128; BR 9609445 A 19960620; CA 2225627 A 19960620; CN 96196661 A 19960620; CZ 422197 A 19960620; EA 199800109 A 19960620; EP 96922030 A 19960620; HU P9901153 A 19960620; IL 12265096 A 19960620; JP 50477297 A 19960620; KR 19970709952 A 19971230; MA 24298 A 19960628; MX 9800186 A 19980107; NO 976158 A 19971230; NZ 31168496 A 19960620; OA 70172 A 19971231; PE 00049696 A 19960628; PL 32424096 A 19960620; SK 178497 A 19960620; TR 9701762 T 19960620