EP 0840751 A1 19980513 - MONOCLONAL ANTIBODY CAPABLE OF BINDING TO PNA/NUCLEIC ACID COMPLEXES
Title (en)
MONOCLONAL ANTIBODY CAPABLE OF BINDING TO PNA/NUCLEIC ACID COMPLEXES
Title (de)
MONOKLONALER ANTIKÖRPER DER FÄHIG IST, AN PNA/NUKLEINSÄUREKOMPLEXEN ZU BINDEN
Title (fr)
ANTICORPS MONOCLONAL POUVANT SE FIXER A DES COMPLEXES DE PNA/ACIDES NUCLEIQUES
Publication
Application
Priority
- DK 9500485 W 19951201
- DK 71895 A 19950622
Abstract (en)
[origin: WO9614341A1] Monoclonal antibodies capable of binding to complexes formed between PNA (<u>P</u>eptide <u>N</u>ucleic <u>A</u>cid) and nucleic acids, particularly to PNA/DNA or PNA/RNA complexes, are described. The preferred monoclonal antibodies are capable of binding to PNA/DNA or PNA/RNA complexes, but not to single-stranded PNAs, double-stranded nucleic acids or single-stranded nucleic acids. PNAs are newly developed, not naturally occurring compounds of which some have a polyamide backbone bearing a plurality of ligands such as naturally occurring nucleobases attached to the backbone through a suitable linker. Some PNAs have been shown to possess a surprisingly high affinity for complementary nucleic acid forming very stable and specific complexes. Such PNAs are thus suitable as hybridization probes for detection of nucleic acids. The antibodies now provided render these PNAs very usable as hybridization probes. The antibodies provided are useful in the capture, recognition, detection, identification or quantitation of nucleic acids in biological samples, via their ability to react with PNA-nucleic acid complexes.
IPC 1-7
IPC 8 full level
C12N 15/02 (2006.01); C07K 16/44 (2006.01); C12N 5/10 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP)
C07K 16/44 (2013.01)
Citation (search report)
See references of WO 9614341A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9614341 A1 19960517; AU 4327196 A 19960531; EP 0840751 A1 19980513; JP H11507202 A 19990629
DOCDB simple family (application)
DK 9500485 W 19951201; AU 4327196 A 19951201; EP 95942055 A 19951201; JP 51496896 A 19951201