EP 0845035 A2 19980603 - UROCORTIN PEPTIDES
Title (en)
UROCORTIN PEPTIDES
Title (de)
UROCORTIN PEPTIDEN
Title (fr)
PEPTIDES D'UROCORTINE
Publication
Application
Priority
- US 9610240 W 19960612
- US 49031495 A 19950613
- US 222395 P 19950811
Abstract (en)
[origin: WO9700063A2] Urocortin (Ucn) is a native mammalian peptide generally related to Urotensin I and Corticotropin Releasing Factor (CRF). Human Ucn has the formula: Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 (SEQ ID NO:15). Rat-derived Ucn is identical but for 2 substitutions, Asp<2> for Asn<2> and Pro<4> for Ser<4>. Ucn or analogs thereof or pharmaceutically acceptable salts can be administered to humans and other mammals to achieve substantial elevation of ACTH, beta -endorphin, beta -lipotropin, other products of the pro-opiomelanocortin gene and corticosterone. They can also be used to lower blood pressure over an extended period of time, as stimulants to elevate mood and to improve memory and learning performance, as well as diagnostically. Shortened fragments may be administered to release endogenous CRF and/or Ucn in the brain and peripherally. Ucn antagonists can be used to block the action of Ucn and/or CRF, as can antibodies to Ucn. Labelled Ucn agonists and antagonists can be used in drug screening assays along with CRF receptors; they may also be used diagnostically along with Ucn antibodies.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61P 3/00 (2006.01); A61P 9/02 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 15/04 (2006.01); A61P 25/22 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07K 14/575 (2006.01); C07K 16/26 (2006.01); C12N 15/09 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 9/02 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 15/04 (2017.12); A61P 25/22 (2017.12); A61P 25/28 (2017.12); A61P 29/00 (2017.12); A61P 37/02 (2017.12); A61P 43/00 (2017.12); C07K 14/57509 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9700063A2
Designated contracting state (EPC)
CH DE ES FR GB IT LI
DOCDB simple family (publication)
WO 9700063 A2 19970103; WO 9700063 A3 19970123; AU 6277796 A 19970115; CA 2223792 A1 19970103; EP 0845035 A2 19980603; JP 2002504802 A 20020212
DOCDB simple family (application)
US 9610240 W 19960612; AU 6277796 A 19960612; CA 2223792 A 19960612; EP 96921584 A 19960612; JP 50331297 A 19960612