EP 0845045 A1 19980603 - REGULATION OF CELLULAR FUNCTIONS BY ECTOPIC EXPRESSION OF NON-ENDOGENOUS CELL SIGNALLING RECEPTORS
Title (en)
REGULATION OF CELLULAR FUNCTIONS BY ECTOPIC EXPRESSION OF NON-ENDOGENOUS CELL SIGNALLING RECEPTORS
Title (de)
REGULATION ZELLULÄRER FUNKTIONEN DURCH EKTOPISCHE EXPRESSION NICHT-ENDOGENER ZELLSIGNALISIERUNGSREZEPTOREN
Title (fr)
REGULATION DE FONCTIONS CELLULAIRES A L'AIDE D'UNE EXPRESSION ECTOPIQUE DE RECEPTEURS NON ENDOGENES DE SIGNALISATION DE CELLULE
Publication
Application
Priority
- US 9613077 W 19960812
- US 225495 P 19950814
Abstract (en)
[origin: WO9707233A1] The present invention is directed to an in vivo cell transformed with DNA encoding a cell signalling receptor not endogenous to the cell. The cell signalling receptor is capable of activating a signal transduction pathway endogenous to the cell, and the cell signalling receptor can be controllably activated thereby controllably activating the signal transduction pathway so as to regulate a cell function controlled by the signal transduction pathway. The invention also provides a method of ectopically expressing a non-endogenous receptor in a cell, and a method of regulating a cell function in vivo. The method of regulating a cell function comprises transforming a cell with DNA encoding a cell signalling receptor not endogenous to the cell, as above, and controllably exposing the cell to an extracellular molecule capable of activating the foreign cell signalling receptor. Activation of the cell signalling receptor activates the endogenous signal transduction pathway so as to regulate a cell function controlled by the endogenous signal transduction pathway.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/00 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C07K 14/72 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01); A61K 38/00 (2006.01); C12R 1/91 (2006.01); C12R 1/92 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C07K 14/72 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI NL SE
DOCDB simple family (publication)
WO 9707233 A1 19970227; AU 6772196 A 19970312; AU 716407 B2 20000224; CA 2229287 A1 19970227; EP 0845045 A1 19980603; EP 0845045 A4 19991124; JP H11510704 A 19990921
DOCDB simple family (application)
US 9613077 W 19960812; AU 6772196 A 19960812; CA 2229287 A 19960812; EP 96928135 A 19960812; JP 50940497 A 19960812