Global Patent Index - EP 0845990 A4

EP 0845990 A4 20010214 - NEW USE OF PREGNANE-DIONES AS ANALGESIC AGENTS

Title (en)

NEW USE OF PREGNANE-DIONES AS ANALGESIC AGENTS

Title (de)

NEUE VERWENDUNG VON PREGNANDIONEN ALS ANALGETIKA

Title (fr)

NOUVEL EMPLOI DE PREGNANES-DIONES COMME ANALGESIQUES

Publication

EP 0845990 A4 20010214 (EN)

Application

EP 96927448 A 19960823

Priority

  • AU 9600531 W 19960823
  • AU PN498095 A 19950823

Abstract (en)

[origin: WO9707807A1] The present invention provides: the new use of compounds of formula (II) wherein R<1> is H or Me, preferably H; R<2> is OH, preferably in alpha conformation; R<3> is H, or R<2> and R<3>, taken together, are O; R<4> is H or Me, preferably Me, and preferably in alpha conformation; R<5> is H; R<6> is H; or R<5> and R6, taken together, are O; R<7> is H or Me, preferably H; R<8> is H, Me or -CH2 O CO CH3. The present invention also provides a method of analgesia comprising administering an effective amount of a compound of formula (II) wherein R<1> est H or Me, preferably H; R<2> is OH, preferably in alpha conformation; R<3> is H, or R<2> and R<3>, taken together, are O; R<4> is H or Me, preferably Me, and preferably in alpha conformation; R<5> is H; R<6> is H; or R<5> and R<6>, taken together, are O; R<7> is H or Me, preferably H; R<8> is H, Me or -CH2 O CO CH3. The present invention also provides an analgesic composition comprising a compound of formula (II) wherein R<1> is H or Me, preferably H; R<2> is OH, preferably in alpha conformation; R<3> is H, or R<2> and R<3>, taken together, are O; R<4> is H or Me, preferably Me, and preferably in alpha conformation; R<5> is H; R<6> is H; or R<5> and R<6>, taken together, are O; R<7> is H or Me, preferably H; R<8> is H, Me or -CH2 O CO CH3 together with a pharmaceutically acceptable diluent.

IPC 1-7

A61K 31/57

IPC 8 full level

A61K 31/56 (2006.01); A61K 31/57 (2006.01)

CPC (source: EP)

A61K 31/56 (2013.01); A61K 31/57 (2013.01); A61K 31/573 (2013.01); A61P 25/04 (2017.12)

Citation (search report)

  • [X] US 5439900 A 19950808 - BUKUSOGLU CUNEYT [US], et al
  • [X] ERIKSSON H ET AL: "Comparison of eltanolone and thiopental in anaesthesia for termination of pregnancy.", ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol. 39, no. 4, 1995, pages 479 - 484, XP000965595, ISSN: 0001-5172
  • [X] CARL...: "pharmacokinetics and pharmacodynamics of...", ACTA ANESTHESIOLOGY SCAND., vol. 38, no. 7, 1994, pages 734 - 741, XP000965594
  • [XA] SELYE: "correlations between...", ENDOCRINOLOGY, vol. 30, 1942, pages 437 - 453, XP000974346
  • See references of WO 9707807A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9707807 A1 19970306; AU PN498095 A0 19950914; EP 0845990 A1 19980610; EP 0845990 A4 20010214

DOCDB simple family (application)

AU 9600531 W 19960823; AU PN498095 A 19950823; EP 96927448 A 19960823