EP 0846127 A1 19980610 - ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY
Title (en)
ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY
Title (de)
ACYLIERTE OLIGOPEPTIDDERIVATE MIT ZELL-SIGNAL INHIBIERENDER AKTIVITÄT
Title (fr)
DERIVES OLIGOPEPTIDIQUES ACYLES PRESENTANT UNE ACTIVITE INHIBANT DES SIGNAUX CELLULAIRES
Publication
Application
Priority
- EP 9603473 W 19960806
- GB 9517060 A 19950817
Abstract (en)
[origin: WO9708193A1] The invention relates to an acylated peptide, namely a compound of formula (I), wherein n is 0 to 15, X is arylcarbonyl, cycloalkylcarbonyl, tricycloalkylcarbonyl, arylsulfonyl, heterocyclylcarbonyl, heterocyclylsulfonyl, carbamoyl-lower alkanoyl, aryl-lower alkylcarbonyl, cycloalkyl-lower alkylcarbonyl, aryl-lower alkylsulfonyl, heterocyclyl-lower alkylcarbonyl, heterocyclyl-lower alkylsulfonyl with the proviso that in any of the lower alkyl radicals mentioned a methylene group may be replaced with oxa, aza or thia; heterocyclyl-lower alkenylcarbonyl or aryl-lower alkenylcarbonyl; or, if Y is a secondary or tertiary amino group, is one of the moieties X mentioned above or lower alkanoyl, halo-lower alkanoyl, lower-alkoxycarbonyl, aryl-lower alkoxycarbonyl or cycloalkyl-lower alkoxycarbonyl; PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimic, AA stands for a bivalent radical of a natural or unnatural amino acid, and Y is hydroxy, a C-terminal protecting group or a primary, secondary or tertiary amino group, or a salt thereof, said compound being useful for the treatment of diseases that respond to inhibition of the interaction of (a) protein(s) comprising (an) SH2 domain(s) and a protein tyrosine kinase or a modified version thereof.
IPC 1-7
C07K 5/065; C07K 5/087; C07K 5/107; C07K 14/71; A61K 38/05; A61K 38/06; A61K 38/07; A61K 38/17
IPC 8 full level
C07K 5/02 (2006.01); C07K 5/06 (2006.01); C07K 5/08 (2006.01); C07K 5/10 (2006.01); C07K 14/71 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 5/0202 (2013.01); C07K 5/0207 (2013.01); C07K 5/06191 (2013.01); C07K 5/0827 (2013.01); C07K 5/1027 (2013.01); C07K 14/71 (2013.01); A61K 38/00 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
See references of WO 9708193A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9708193 A1 19970306; AU 6742596 A 19970319; CA 2227516 A1 19970306; EP 0846127 A1 19980610; GB 9517060 D0 19951025; ZA 966967 B 19970217
DOCDB simple family (application)
EP 9603473 W 19960806; AU 6742596 A 19960806; CA 2227516 A 19960806; EP 96927694 A 19960806; GB 9517060 A 19950817; ZA 966967 A 19960816