Title (en)

COMPOUNDS AND METHODS

Title (de)

VERBINDUNGEN UND VERFAHREN DAZU

Title (fr)

COMPOSES ET PROCEDES ASSOCIES

Publication

EP 0851759 A4 20001206 (EN)

Application

EP 96930743 A 19960905

Priority

• US 9614347 W 19960905
• US 355695 P 19950905

Abstract (en)

[origin: WO9709046A1] This invention relates to quinine and quinidine compounds which are ligands, in particular, antagonists, of the Calcitonin Gene-Related Peptide ("CGRP") receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CGRP, including, but not limited to, headaches, especially migraines; non-insulin dependent diabetes mellitus; cardiovascular disorders; chronic inflammation; endotoxic shock; arthritis; allergic rhinits; and asthma, all in mammals, by the use of quinine and quinidine CGRP receptor antagonists.

IPC 1-7

A61K 31/49; C07D 453/04

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/49 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 5/00 (2006.01); A61P 5/22 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 25/06 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07D 453/02 (2006.01); C07D 453/04 (2006.01)

CPC (source: EP)

A61K 31/49 (2013.01); A61P 3/00 (2017.12); A61P 3/10 (2017.12); A61P 5/00 (2017.12); A61P 5/22 (2017.12); A61P 9/00 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 25/06 (2017.12); A61P 29/00 (2017.12); A61P 37/00 (2017.12); C07D 453/02 (2013.01)

Citation (search report)

• [A] DAINES R A ET AL: "Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 7, no. 20, 21 October 1997 (1997-10-21), pages 2673 - 2676, XP004136510, ISSN: 0960-894X
• See references of WO 9709046A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

DOCDB simple family (publication)

WO 9709046 A1 19970313; EP 0851759 A1 19980708; EP 0851759 A4 20001206; JP H11512396 A 19991026

DOCDB simple family (application)

US 9614347 W 19960905; EP 96930743 A 19960905; JP 51142097 A 19960905