EP 0853479 A1 19980722 - ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS
Title (en)
ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS
Title (de)
ALPHA 1B ADRENERGISCHER REZEPTORANTAGONISTEN
Title (fr)
ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b
Publication
Application
Priority
- GB 9604288 A 19960229
- US 9615223 W 19960924
- US 450195 P 19950929
Abstract (en)
[origin: WO9711698A1] This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha 1b adrenergic receptor antagonists. These compounds display submicromolar affinity for the human alpha 1b adrenergic receptor subtype while displaying at least five-fold lower affinity for the human alpha 1d and alpha 1a adrenergic receptor subtypes, and many other G-protein coupled human receptors. One application of these compounds is in the treatment of hypertension. More specifically, these compounds display selectivity for lowering blood pressure without, for example, substantially affecting urethral pressure.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/505 (2006.01); A61K 31/517 (2006.01); A61K 31/529 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); A61P 13/00 (2006.01); A61P 13/08 (2006.01); A61P 43/00 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 9/12 (2017.12); A61P 13/00 (2017.12); A61P 13/08 (2017.12); A61P 43/00 (2017.12); C07D 403/04 (2013.01); C07D 405/14 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9711698 A1 19970403; CA 2232138 A1 19970403; EP 0853479 A1 19980722; EP 0853479 A4 20010411; JP H11512710 A 19991102
DOCDB simple family (application)
US 9615223 W 19960924; CA 2232138 A 19960924; EP 96933093 A 19960924; JP 51353297 A 19960924