EP 0854929 A1 19980729 - RECOMBINANT VIRUSES INCORPORATING A PROTEASE CLEAVABLE PROTEIN
Title (en)
RECOMBINANT VIRUSES INCORPORATING A PROTEASE CLEAVABLE PROTEIN
Title (de)
REKOMBINANTE VIREN, DIE EIN BEI EINER PROTEASE SPALTBARES PROTEIN ENTHALTEN
Title (fr)
VIRUS RECOMBINES COMPRENANT UNE PROTEINE POUVANT ETRE CLIVEE PAR UNE PROTEASE
Publication
Application
Priority
- GB 9602381 W 19960927
- GB 9519691 A 19950927
- GB 9523225 A 19951114
- GB 9604562 A 19960304
Abstract (en)
[origin: WO9712048A1] Disclosed is a recombinant viral particle capable of infecting a eukaryotic cell, the viral particle comprising: a substantially intact viral glycoprotein fused, via an intervening linker region, to a heterologous polypeptide displayed on the surface of the particle, which heterologous polypeptide modulates the ability of the viral particle to infect one or more eukaryotic cell types and is cleavable from the viral glycoprotein by a protease acting selectively on a specific protease cleavage site present in the linker region, such that cleavage of the heterologous polypeptide from the viral glycoprotein allows the glycoprotein to interact normally with its cognate receptor on the surface of a target cell.
IPC 1-7
C12N 15/86; C12N 7/00; C12N 15/62; A61K 48/00; C07K 14/16; C07K 14/485; C12Q 1/68; C07K 14/525; C07K 14/705
IPC 8 full level
C12N 15/09 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/15 (2006.01); C07K 14/485 (2006.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); C12N 7/00 (2006.01); C12N 15/00 (2006.01); C12N 15/62 (2006.01); C12N 15/867 (2006.01); C12Q 1/68 (2006.01); C12R 1/92 (2006.01)
CPC (source: EP)
A61K 47/6901 (2017.07); C07K 14/005 (2013.01); C07K 14/485 (2013.01); C07K 14/525 (2013.01); C07K 14/705 (2013.01); C12N 7/00 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); C12Q 1/6811 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/50 (2013.01); C07K 2319/61 (2013.01); C07K 2319/735 (2013.01); C07K 2319/75 (2013.01); C12N 2740/13022 (2013.01); C12N 2740/13043 (2013.01)
Citation (search report)
See references of WO 9712048A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9712048 A1 19970403; AU 7091196 A 19970417; AU 716466 B2 20000224; CA 2232669 A1 19970403; EP 0854929 A1 19980729; JP H11513249 A 19991116
DOCDB simple family (application)
GB 9602381 W 19960927; AU 7091196 A 19960927; CA 2232669 A 19960927; EP 96931908 A 19960927; JP 51322497 A 19960927