EP 0856067 A1 19980805 - A BINARY CODING METHOD FOR USE IN COMBINATORIAL CHEMISTRY
Title (en)
A BINARY CODING METHOD FOR USE IN COMBINATORIAL CHEMISTRY
Title (de)
EINE BINÄRE KODIERUNGSMETHODE ZUR VERWENDUNG IN KOMBINATORISCHER CHEMIE
Title (fr)
PROCEDE DE CODAGE BINAIRE DESTINE A ETRE UTILISE EN CHIMIE COMBINATOIRE
Publication
Application
Priority
- US 9616718 W 19961018
- US 562395 P 19951019
Abstract (en)
[origin: WO9714814A1] The present invention is to a technique for labeling a ligand or compounds covalently bound to solid-phase-synthesis resin with a tag containing <13>C and/or <15>N. This tagging along with high-resolution isotope filtered <1>H NMR, and Magic Angle Spinning probes provides for a technique which is general, nondestructive, and leaves the resin-bound sample intact and available for further chemical transformations. The limit of detection (< 800 pmol) in this system is sufficient to allow NMR to be used in deciphering the contents of a "one-bead, one-compound" combinatorial chemistry library.
IPC 1-7
C12Q 1/68; G01N 33/53; G01N 33/543; G01N 33/544; G01N 33/545; G01N 33/546; G01N 33/573
IPC 8 full level
G01R 33/465 (2006.01); C07B 61/00 (2006.01); C12Q 1/68 (2006.01); G01N 24/08 (2006.01); G01N 33/534 (2006.01); C40B 70/00 (2006.01)
CPC (source: EP)
C40B 50/16 (2013.01); C40B 70/00 (2013.01); B01J 2219/005 (2013.01); B01J 2219/00572 (2013.01)
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9714814 A1 19970424; EP 0856067 A1 19980805; EP 0856067 A4 20050921; JP 2000500565 A 20000118
DOCDB simple family (application)
US 9616718 W 19961018; EP 96936686 A 19961018; JP 51603797 A 19961018