EP 0857071 A1 19980812 - (RADIO) LABELLED BIOTIN DERIVATIVES
Title (en)
(RADIO) LABELLED BIOTIN DERIVATIVES
Title (de)
(RADIO)MARKIERTE BIOTIN-DERIVATE
Title (fr)
COMPOSES DE BIOTINE (RADIO) MARQUES
Publication
Application
Priority
- EP 96933801 A 19960917
- EP 95202512 A 19950918
- US 9614883 W 19960917
Abstract (en)
[origin: WO9710854A1] The invention relates to a labelled biotin compound, wherein said biotin compound is represented by general formula (I) wherein: n is 1 or 2, R is a chelating group for chelating a metal atom, and Sp is a spacing group having at least 4 atoms spacing NH from R; and wherein said biotin compound is labelled with a metal atom selected from (a) the group consisting of the radioactive isotopes <99m>Tc, <203>Pb, <66>Ga, <67>Ga, <68>Ga, <72>As, <111>In, <113m>In, <114m>In, <97>Ru, <62>Cu, <64>Cu, <52>Fe, <52m>Mn, <51>Cr, <186>Re, <188>Re, <77>As, <90>Y, <67>Cu, <169>Er, <117m>Sn, <121>Sn, <127>Te, <142>Pr, <143>Pr, <198>Au, <199>Au, <149>Tb, <161>Tb, <109>Pd, <165>Dy, <149>Pm, <151>Pm, <153>Sm, <157>Gd, <166>Ho, <172>Tm, <169>Yb, <175>Yb, <177>Lu, <105>Rh and <111>Ag or (b) the group consisting of the paramagnetic metal atoms Cr, Mn, Fe, Co, Ni, Cu, Pr, Nd, Sm, Yb, Gd, Tb, Dy, Ho and Er; said metal atom being attached to the biotin compound by means of said chelating group. The invention further relates to a pharmaceutical composition comprising said labelled biotin compound, to the use of said composition for diagnosis and therapy, and to a kit for preparing a radiopharmaceutical composition.
IPC 1-7
IPC 8 full level
C07D 495/04 (2006.01); A61K 31/00 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/4166 (2006.01); A61K 38/00 (2006.01); A61K 49/00 (2006.01); A61K 49/08 (2006.01); A61K 51/00 (2006.01); A61K 51/04 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 49/085 (2013.01); A61K 49/10 (2013.01); A61K 51/0497 (2013.01); A61P 35/00 (2017.12); A61K 2121/00 (2013.01); A61K 2123/00 (2013.01)
Citation (search report)
See references of WO 9710854A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9710854 A1 19970327; CA 2232411 A1 19970327; CZ 75498 A3 19990915; EP 0857071 A1 19980812; IL 123725 A0 19981206; JP H11513374 A 19991116; MX 9802107 A 19980830; NO 981202 D0 19980317; NO 981202 L 19980518
DOCDB simple family (application)
US 9614883 W 19960917; CA 2232411 A 19960917; CZ 75498 A 19960917; EP 96933801 A 19960917; IL 12372598 A 19980318; JP 51283397 A 19960917; MX 9802107 A 19980317; NO 981202 A 19980317