EP 0858444 A4 19991201 - CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS

Title (en)

CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS

Title (de)

CYCLOPENTYL-TACHYKININRECEPTORANTAGONISTEN

Title (fr)

ANTAGONISTES DES RECEPTEURS DE LA CYCLOPENTYLE-TACHYKININE

Publication

EP 0858444 A4 19991201 (EN)

Application

EP 96941315 A 19961015

Priority

GB 9602853 A 19960213
US 9616489 W 19961015
US 555895 P 19951018

Abstract (en)

[origin: WO9714671A1] The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R<3>, R<6>, R<7>, R<8>, R<11>, R<12>, R<13>, A, Q, W, X, Y, Z and n are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulation in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

IPC 1-7

C07C 69/757; A61K 31/215

IPC 8 full level

A61K 31/16 (2006.01); A61K 31/215 (2006.01); A61K 31/34 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/40 (2006.01); A61K 31/4015 (2006.01); A61K 31/404 (2006.01); A61K 31/41 (2006.01); A61K 31/4166 (2006.01); A61K 31/4178 (2006.01); A61K 31/4192 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/4245 (2006.01); A61K 31/425 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/429 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61K 31/505 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61P 1/08 (2006.01); A61P 11/06 (2006.01); A61P 25/06 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07C 43/192 (2006.01); C07C 43/196 (2006.01); C07C 62/32 (2006.01); C07C 62/38 (2006.01); C07C 69/757 (2006.01); C07C 217/52 (2006.01); C07C 229/48 (2006.01); C07C 233/81 (2006.01); C07C 237/06 (2006.01); C07C 265/10 (2006.01); C07C 271/24 (2006.01); C07C 275/26 (2006.01); C07D 207/16 (2006.01); C07D 207/26 (2006.01); C07D 207/38 (2006.01); C07D 209/08 (2006.01); C07D 211/14 (2006.01); C07D 211/16 (2006.01); C07D 211/58 (2006.01); C07D 211/62 (2006.01); C07D 213/30 (2006.01); C07D 213/38 (2006.01); C07D 213/61 (2006.01); C07D 215/18 (2006.01); C07D 215/20 (2006.01); C07D 233/32 (2006.01); C07D 233/61 (2006.01); C07D 233/70 (2006.01); C07D 233/86 (2006.01); C07D 239/26 (2006.01); C07D 249/08 (2006.01); C07D 249/12 (2006.01); C07D 257/04 (2006.01); C07D 261/08 (2006.01); C07D 263/32 (2006.01); C07D 271/06 (2006.01); C07D 271/10 (2006.01); C07D 277/28 (2006.01); C07D 277/64 (2006.01); C07D 295/08 (2006.01); C07D 295/12 (2006.01); C07D 295/18 (2006.01); C07D 307/42 (2006.01); C07D 307/52 (2006.01); C07D 307/64 (2006.01); C07D 307/79 (2006.01); C07D 307/82 (2006.01); C07D 307/92 (2006.01); C07D 333/20 (2006.01); C07D 333/32 (2006.01); C07D 333/38 (2006.01); C07D 333/58 (2006.01); C07D 401/04 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 417/10 (2006.01); C07D 417/12 (2006.01); C07D 513/04 (2006.01); C07D 521/00 (2006.01); C07J 73/00 (2006.01)

CPC (source: EP)

A61P 1/08 (2017.12); A61P 11/06 (2017.12); A61P 25/06 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07C 69/757 (2013.01); C07C 217/52 (2013.01); C07C 229/48 (2013.01); C07C 233/81 (2013.01); C07C 237/06 (2013.01); C07D 207/16 (2013.01); C07D 207/26 (2013.01); C07D 209/08 (2013.01); C07D 211/14 (2013.01); C07D 211/58 (2013.01); C07D 211/62 (2013.01); C07D 213/38 (2013.01); C07D 213/61 (2013.01); C07D 215/18 (2013.01); C07D 215/20 (2013.01); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 233/86 (2013.01); C07D 239/26 (2013.01); C07D 249/08 (2013.01); C07D 249/12 (2013.01); C07D 257/04 (2013.01); C07D 261/08 (2013.01); C07D 271/06 (2013.01); C07D 271/10 (2013.01); C07D 277/28 (2013.01); C07D 277/64 (2013.01); C07D 307/52 (2013.01); C07D 307/64 (2013.01); C07D 307/92 (2013.01); C07D 333/20 (2013.01); C07D 333/32 (2013.01); C07D 333/38 (2013.01); C07D 401/04 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 513/04 (2013.01); C07J 73/006 (2013.01); C07C 2601/08 (2017.04)

Citation (search report)

[A] WO 9407843 A1 19940414 - MERCK SHARP & DOHME [GB], et al
[AP] EP 0686629 A2 19951213 - LILLY CO ELI [US]
See references of WO 9714671A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9714671 A1 19970424; AU 1049797 A 19970507; AU 722883 B2 20000810; EP 0858444 A1 19980819; EP 0858444 A4 19991201; JP 2002534955 A 20021015

DOCDB simple family (application)

US 9616489 W 19961015; AU 1049797 A 19961015; EP 96941315 A 19961015; JP 51592997 A 19961015