Global Patent Index - EP 0859779 A4

EP 0859779 A4 2000-04-12 - INTERLEUKIN CONVERTING ENZYME AND APOPTOSIS

Title (en)

INTERLEUKIN CONVERTING ENZYME AND APOPTOSIS

Title (de)

INTERLEUKIN-KONVERTIERENDES ENZYM UND APOPTOSIS

Title (fr)

ENZYME DE CONVERSION D'INTERLEUKINE ET APOPTOSE

Publication

EP 0859779 A4 (EN)

Application

EP 96932941 A

Priority

  • US 9613967 W
  • US 308295 P

Abstract (en)

[origin: WO9708174A1] The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of ICE and ICE-like proteins for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.

IPC 1-7 (main, further and additional classification)

C07D 501/00; A61K 31/545

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 31/545 (2006.01); A61K 31/546 (2006.01); A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 25/28 (2006.01); A61P 31/00 (2006.01); A61P 31/12 (2006.01); A61P 43/00 (2006.01); C07D 501/00 (2006.01)

CPC (invention and additional information)

C07D 501/00 (2013.01)

Citation (search report)

  • [X] EP 0124081 A2 19841107 - MERCK & CO INC [US]
  • [X] EP 0267723 A2 19880518 - MERCK & CO INC [US]
  • [X] EP 0411929 A1 19910206 - MERCK & CO INC [US]
  • [X] WO 8910926 A1 19891116 - ERBA CARLO SPA [IT]
  • [X] WO 9104977 A1 19910418 - SYNPHAR LAB INC [CA]
  • [X] WO 9428003 A1 19941208 - ERBA CARLO SPA [IT], et al
  • [X] WO 9502603 A2 19950126 - PHARMACIA SPA [IT], et al
  • [X] DE 4341332 A1 19940609 - ERBA CARLO SPA [IT]
  • [X] GB 2266526 A 19931103 - MERCK & CO INC [US]
  • [X] GB 2266525 A 19931103 - MERCK & CO INC [US]
  • [X] P E FINKE ET AL: "Inhibition of Human Leukocyte Elastase. 4. Selection of a Substituted Cephalosporin (L-658,758) as a Topical Aerosol", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 35, 1992, pages 3731 - 3744, XP002077983, ISSN: 0022-2623
  • [X] M. ALPEGIANI ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, 1994, WASHINGTON US, pages 4003 - 4019, XP002077984
  • [X] SALYI, SZABOLCS ET AL: "An improved stereospecific preparation of 7.alpha.- alkoxycephalosporins", SYNTH. COMMUN. (1996), 26(3), 445-52, XP002126770
  • [X] ALPEGIANI, MARCO ET AL: "Studies on cephem sulfones as mechanism-based inactivators of human leukocyte elastase. III. Reactions ensuing from chemical.beta.-lactam cleavage", BIOORG. MED. CHEM. LETT. (1993), 3(11), 2259-64, XP002126771
  • [X] RIZZO, VINCENZO ET AL: "Studies on cephem sulfones as mechanism-based inactivators of human leukocyte elastase. IV. Reactions ensuing from enzymic.beta.-lactam cleavage", BIOORG. MED. CHEM. LETT. (1993), 3(11), 2265-70, XP002126772
  • [X] APLIN, ROBIN T. ET AL: "An investigation into the mechanism of elastase inhibition by cephalosporins using electrospray ionization mass spectrometry", TETRAHEDRON (1993), 49(47), 10903-12, XP002126773
  • [X] ALPEGIANI, M. ET AL: "Synthesis and evaluation of new elastase inhibitors. I. 1,1-Dioxocephem-4-[carboxylic acid] thiol esters", EUR. J. MED. CHEM. (1992), 27(9), 875-90, XP000857084
  • [X] BORGHI, DANIELA ET AL: "Ring conformation and proton NMR spectra of cephem sulfones. Origin and diagnostic value of the H-6, H-2.alpha. long-range coupling", GAZZ. CHIM. ITAL. (1991), 121(5), 273-5, XP002126775
  • [X] ALPEGIANI, MARCO ET AL: "Unexpected reaction between DCC and cephalosporanic acid sulphones", HETEROCYCLES (1990), 31(1), 139-47, XP002126776
  • [X] SHAH, SHRENIK K. ET AL: "Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins", J. MED. CHEM. (1990), 33(9), 2529-35, XP000857087
  • [X] FINKE, PAUL E. ET AL: "Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides", J. MED. CHEM. (1990), 33(9), 2522-8, XP000857086
  • [X] DOHERTY, JAMES B. ET AL: "Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters", J. MED. CHEM. (1990), 33(9), 2513-21, XP000857085
  • [X] HAGMANN, WILLIAM K. ET AL: "Inhibition of human leukocyte elastase by C-2 substituted cephalosporin sulfones", EUR. J. MED. CHEM. (1989), 24(6), 599-604, XP000651452
  • [X] BLACKLOCK, THOMAS J. ET AL: "A versatile synthesis of 1,1-dioxo 7-substituted cephems: preparation of the human leukocyte elastase (HLE) inhibitor 1,1-dioxo-trans-7-methoxycephalosporanic acid tert-butyl ester", J. ORG. CHEM. (1989), 54(16), 3907-13, XP002126781
  • [X] DOHERTY, JAMES B. ET AL: "Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase", NATURE (LONDON) (1986), 322(6075), 192-4, XP002126782
  • See also references of WO 9708174A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9708174 A1 19970306; EP 0859779 A1 19980826; EP 0859779 A4 20000412; JP H11511463 A 19991005

INPADOC legal status


2000-11-15 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20000524

2000-04-12 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000225

2000-04-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): BE CH DE ES FR GB IT LI NL

1998-08-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19980223

1998-08-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE ES FR GB IT LI NL