EP 0862435 A4 19990203 - INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

INHIBITOREN DER FARNESYL-PROTEIN-TRANSFERASE

Title (fr)

INHIBITEURS DE LA FARNESYL-PROTEINE TRANSFERASE

Publication

EP 0862435 A4 19990203 (EN)

Application

EP 96942798 A 19961118

Priority

GB 9604311 A 19960229
US 9618811 W 19961118
US 749895 P 19951122

Abstract (en)

[origin: WO9718813A1] The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

IPC 1-7

A61K 31/445; C07D 401/12

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61K 31/4465 (2006.01); A61K 31/4523 (2006.01); A61K 31/454 (2006.01); A61K 31/535 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61P 9/00 (2006.01); A61P 13/00 (2006.01); A61P 13/12 (2006.01); A61P 27/00 (2006.01); A61P 27/02 (2006.01); A61P 31/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 233/24 (2006.01); C07D 401/12 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 13/00 (2017.12); A61P 13/12 (2017.12); A61P 27/00 (2017.12); A61P 27/02 (2017.12); A61P 31/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 233/24 (2013.01); C07D 401/12 (2013.01)

Citation (search report)

[X] WO 9500507 A1 19950105 - BOOTS CO PLC [GB], et al
[X] WO 9312107 A1 19930624 - SCHERING CORP [US]
[X] WO 9109030 A1 19910627 - RHONE POULENC SANTE [FR]
[X] EP 0197840 A1 19861015 - INST NAT SANTE RECH MED [FR], et al
[A] EP 0675112 A1 19951004 - BRISTOL MYERS SQUIBB CO [US]
See references of WO 9718813A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9718813 A1 19970529; AU 1162697 A 19970611; AU 704139 B2 19990415; CA 2238081 A1 19970529; EP 0862435 A1 19980909; EP 0862435 A4 19990203; JP 2000500502 A 20000118

DOCDB simple family (application)

US 9618811 W 19961118; AU 1162697 A 19961118; CA 2238081 A 19961118; EP 96942798 A 19961118; JP 51994197 A 19961118