EP 0862578 A1 19980909 - ACTINOMYCIN D ANALOGUES
Title (en)
ACTINOMYCIN D ANALOGUES
Title (de)
ACTINOMYCIN D - ANALOG
Title (fr)
ANALOGUES DE L'ACTINOMYCINE D
Publication
Application
Priority
- DK 9600386 W 19960912
- DK 100995 A 19950912
Abstract (en)
[origin: WO9710263A1] The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by alpha -amino acids, beta -amino acids and/or longer chain omega -amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 31/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07K 1/04 (2006.01); C07K 7/06 (2006.01)
CPC (source: EP)
A61P 31/00 (2017.12); A61P 31/04 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); C07K 1/047 (2013.01); C07K 7/06 (2013.01)
Citation (search report)
See references of WO 9710263A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9710263 A1 19970320; AU 6869896 A 19970401; EP 0862578 A1 19980909; JP 2000501068 A 20000202
DOCDB simple family (application)
DK 9600386 W 19960912; AU 6869896 A 19960912; EP 96929190 A 19960912; JP 51157797 A 19960912