EP 0863881 A1 19980916 - BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES
Title (en)
BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES
Title (de)
BENZIMIDAZOLDERIVATE UND IHRE VERWENDUNG IN DER VERHÜTUNG UND/ODER DER BEHANDLUNG VON KNOCHENKRANKHEITEN
Title (fr)
DERIVES BENZIMIDAZOLIQUES, ET LEUR UTILISATION DANS LA PREVENTION ET LE TRAITEMENT DE MALADIES OSSEUSES
Publication
Application
Priority
- GB 9518552 A 19950911
- JP 9602530 W 19960905
Abstract (en)
[origin: WO9710219A1] The present invention relates to a new heterocyclic compound of formula (I), wherein R<1> is acyl, lower alkenyl or lower alkyl optionally substituted with aryl, a heterocyclic group, etc., R<2> is hydrogen, lower alkyl, hydroxy(lower)alkyl, halo(lower)alkyl, etc., R<3> is hydrogen or halogen, R<4> is a heterocyclic group or aryl, each of which may be substituted with suitable substituent(s), and A is (a) or (b), (wherein R<9> and R<10> are each hydrogen, lower alkyl or substituted lower alkyl), and pharmaceutically acceptable salts thereof which are the inhibitors of bone resorption and bone metabolism, to processes for preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of diseases caused by abnormal bone metabolism in human being or an animal.
IPC 1-7
C07D 235/06; A61K 31/415; C07D 235/08; C07D 235/10; C07D 235/12; C07D 235/24; C07D 235/26; C07D 235/28; C07D 401/06; C07D 401/12; C07D 403/06
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/4184 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4439 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/535 (2006.01); A61K 31/5355 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 31/54 (2006.01); A61K 31/541 (2006.01); A61K 31/542 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 15/00 (2006.01); A61P 19/00 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07D 235/06 (2006.01); C07D 235/08 (2006.01); C07D 235/10 (2006.01); C07D 235/12 (2006.01); C07D 235/24 (2006.01); C07D 235/26 (2006.01); C07D 235/28 (2006.01); C07D 235/30 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 409/06 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 513/04 (2006.01); C07D 521/00 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/10 (2017.12); A61P 15/00 (2017.12); A61P 19/00 (2017.12); A61P 25/28 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 235/08 (2013.01); C07D 235/10 (2013.01); C07D 235/12 (2013.01); C07D 235/24 (2013.01); C07D 235/26 (2013.01); C07D 235/28 (2013.01); C07D 235/30 (2013.01); C07D 249/08 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 513/04 (2013.01)
Citation (search report)
See references of WO 9710219A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9710219 A1 19970320; EP 0863881 A1 19980916; GB 9518552 D0 19951108; JP H11513364 A 19991116
DOCDB simple family (application)
JP 9602530 W 19960905; EP 96929540 A 19960905; GB 9518552 A 19950911; JP 51182497 A 19960905