EP 0863885 A2 19980916 - NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS
Title (en)
NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS
Title (de)
NEUUE MAKROCYCLISCHE VERBINDUNGEN ALS METALLOPROTEASE-INHIBITOREN
Title (fr)
NOUVEAUX COMPOSES MACROCYCLIQUES TENANT LIEU D'INHIBITEURS DE LA METALLOPROTEASE
Publication
Application
Priority
- US 9618382 W 19961113
- US 668495 P 19951114
- US 64690296 A 19960508
- US 74343996 A 19961101
Abstract (en)
[origin: WO9718207A2] This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
IPC 1-7
C07D 267/00; C07D 273/02; C07D 291/02; C07D 245/02; C07D 255/02; C07D 413/12; C07D 417/12; C07D 401/12; C07D 403/12; C07D 419/12; C07D 498/08; C07K 5/06; A61K 31/395; A61K 38/05; C12Q 1/37
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/395 (2006.01); A61K 31/40 (2006.01); A61K 31/407 (2006.01); A61K 31/415 (2006.01); A61K 31/416 (2006.01); A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/42 (2006.01); A61K 31/422 (2006.01); A61K 31/425 (2006.01); A61K 31/427 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61K 31/4465 (2006.01); A61K 31/4523 (2006.01); C12Q 1/37 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/535 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 38/00 (2006.01); A61K 49/00 (2006.01); A61P 29/00 (2006.01); C07D 245/02 (2006.01); C07D 255/02 (2006.01); C07D 267/00 (2006.01); C07D 273/02 (2006.01); C07D 291/02 (2006.01); C07D 291/08 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 419/12 (2006.01); C07D 498/08 (2006.01); C07D 521/00 (2006.01); C07K 5/02 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); C07K 5/068 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP)
A61P 29/00 (2018.01); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 245/02 (2013.01); C07D 249/08 (2013.01); C07D 255/02 (2013.01); C07D 267/00 (2013.01); C07D 273/02 (2013.01); C07D 291/02 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 419/12 (2013.01); C07K 5/0606 (2013.01); C07K 5/06078 (2013.01); C07K 5/06139 (2013.01); C07K 5/06191 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9718207 A2 19970522; WO 9718207 A3 19970724; BR 9611563 A 19990302; CA 2237524 A1 19970522; CN 1202161 A 19981216; CZ 144798 A3 19981014; EE 9800115 A 19981015; EP 0863885 A2 19980916; HR P960533 A2 19980430; HU P0201479 A2 20020828; IL 124366 A0 19981206; JP 2000502050 A 20000222; LV 12167 A 19981120; LV 12167 B 19990320; MX 9803851 A 19980930; NO 982185 D0 19980513; NO 982185 L 19980713; PL 326714 A1 19981026; SI 9620120 A 19990630; SK 63498 A3 19990111
DOCDB simple family (application)
US 9618382 W 19961113; BR 9611563 A 19961113; CA 2237524 A 19961113; CN 96198327 A 19961113; CZ 144798 A 19961113; EE 9800115 A 19961113; EP 96943497 A 19961113; HR P960533 A 19961113; HU P0201479 A 19961113; IL 12436696 A 19961113; JP 51911997 A 19961113; LV 980104 A 19980707; MX 9803851 A 19980514; NO 982185 A 19980513; PL 32671496 A 19961113; SI 9620120 A 19961113; SK 63498 A 19961113