Global Patent Index - EP 0866128 A3

EP 0866128 A3 19981216 - Recombinant ricin toxin

Title (en)

Recombinant ricin toxin

Title (de)

Rekombinantes Ricin-Toxin

Title (fr)

Toxine de ricine-recombinante

Publication

EP 0866128 A3 19981216 (EN)

Application

EP 98200017 A 19861113

Priority

  • EP 86308877 A 19861113
  • US 83758386 A 19860307

Abstract (en)

[origin: EP0866128A2] DNA sequences encoding full length precursor proteins, which proteins contain both A and B portions of two ricin isotoxins and ricin agglutinin, as well as the linker regions have been determined. These DNAs or portions or modifications thereof are expressed in recombinant hosts to obtain the desired proteins or proteins which can readily be converted thereto. One of the ricin isotoxins may be related to ricin E.

IPC 1-7

C12N 15/29; C12N 1/21; C12N 15/70; C07K 14/415; C12P 21/02

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/43 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C12N 15/09 (2006.01); C07K 1/20 (2006.01); C07K 14/00 (2006.01); C07K 14/415 (2006.01); C07K 19/00 (2006.01); C12N 1/00 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 15/00 (2006.01); C12N 15/29 (2006.01); C12P 21/02 (2006.01); G01N 33/536 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP)

A61P 35/00 (2018.01); A61P 37/00 (2018.01); A61P 43/00 (2018.01); C07K 14/415 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/55 (2013.01)

Citation (search report)

  • [DX] WO 8503508 A1 19850815 - CETUS CORP [US]
  • [X] EP 0145111 A1 19850619 - UNIV WARWICK [GB]
  • [X] EP 0169006 A2 19860122 - ICI PLC [GB]
  • [X] KEVIN C. HALLING ET AL.: "Genomic cloning and characterization of a ricin gene from Ricinus communis", NUCLEIC ACIDS RESEARCH, vol. 13, no. 22, 1985, OXFORD GB, pages 8019 - 8032, XP002079748
  • [X] ROBERTS,LYNNE M. ET AL.: "The primary sequence of ricinus communis agglutinin.Comparison with ricin.", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 260, no. 29, 1985, MD US, pages 15682 - 15686, XP002079749
  • [DA] P.COHEN ET AL.: "Molecular aspects of cellular regulation,vol 2:Molecular action of toxins and viruses", 1982, ELSEVIER BIOMEDICAL, AMSTERDAM,NL, XP002060841

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0237676 A2 19870923; EP 0237676 A3 19890329; EP 0237676 B1 19980812; AT E169672 T1 19980815; AU 601956 B2 19900927; AU 6511986 A 19870910; CA 1324095 C 19931109; DE 3650692 D1 19980917; DE 3650692 T2 19990422; DK 551786 A 19870908; DK 551786 D0 19861118; EP 0866128 A2 19980923; EP 0866128 A3 19981216; FI 864626 A0 19861113; FI 864626 A 19870908; JP 3005621 B2 20000131; JP 3010360 B2 20000221; JP H10127295 A 19980519; JP S62232387 A 19871012; NO 864986 D0 19861210; NO 864986 L 19870908

DOCDB simple family (application)

EP 86308877 A 19861113; AT 86308877 T 19861113; AU 6511986 A 19861113; CA 525312 A 19861215; DE 3650692 T 19861113; DK 551786 A 19861118; EP 98200017 A 19861113; FI 864626 A 19861113; JP 26506497 A 19970911; JP 28217386 A 19861128; NO 864986 A 19861210