Global Patent Index - EP 0869802 A4

EP 0869802 A4 20011114 - VERTEBRATE DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES, AND RELATED METHODS AND COMPOSITIONS

Title (en)

VERTEBRATE DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES, AND RELATED METHODS AND COMPOSITIONS

Title (de)

DELTEX PROTEINE, NUKLEINSÄUREN, UND ANTIKÖRPER VON VERTEBRATEN, SOWIE DIESBEZÜGLICHE VERFAHREN UND ZUSAMMENSETZUNGEN

Title (fr)

PROTEINES, ACIDES NUCLEIQUES ET ANTICORPS DELTEX DE VERTEBRES, ET PROCEDES ET COMPOSITIONS RELATIFS A CEUX-CI

Publication

EP 0869802 A4 20011114 (EN)

Application

EP 96942785 A 19961122

Priority

  • US 9618675 W 19961122
  • US 56196395 A 19951122

Abstract (en)

[origin: WO9718822A1] The present invention relates to nucleotide sequences of vertebrate deltex genes, and amino acid sequences of the encoded vertebrate Deltex proteins. The invention further relates to fragments and other derivatives, and analogs, of vertebrate Deltex proteins, as well as antibodies thereto. Nucleic acids encoding such fragments or derivatives are also within the scope of the invention. Production of the foregoing proteins and derivatives, e.g., by recombinant methods is provided. In a specific embodiment, the invention relates to human deltex nucleic acids and proteins. The present invention also relates to therapeutic and diagnostic methods and compositions based on vertebrate Deltex proteins, nucleic acids, and antibodies. The invention also provides methods of inactivating Notch function in a cell, methods of identifying a compound that inhibits or reduces the binding of a vertebrate Deltex protein to a Notch protein, and methods of expanding non-terminally differentiated cells.

IPC 1-7

A61K 35/12; C07H 17/00; C07K 1/00; C07K 14/00; C07K 16/00; C12N 1/00; C12N 5/00; C12N 15/00; C12Q 1/00; C12Q 1/68; C07K 14/47

IPC 8 full level

G01N 33/50 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 35/12 (2015.01); A61K 35/76 (2015.01); A61K 35/761 (2015.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 11/00 (2006.01); A61P 15/00 (2006.01); A61P 35/00 (2006.01); C07K 7/04 (2006.01); C07K 14/07 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)

CPC (source: EP)

A61P 11/00 (2017.12); A61P 15/00 (2017.12); A61P 35/00 (2017.12); C07K 14/47 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [Y] DIEDERICH ET AL.: "Cytosolic interaction between deltex and Notch ankyrin repeats impplicates deltex in the Notch signaling pathway", DEVELOPMENT, vol. 120, 1994, pages 473 - 481, XP010216767
  • [Y] BUSSEAU: "A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein", GENETICS, vol. 136, no. 2, February 1994 (1994-02-01), pages 585-596, XP001018513
  • See references of WO 9718822A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9718822 A1 19970529; AU 1161497 A 19970611; AU 728798 B2 20010118; CA 2238404 A1 19970529; EP 0869802 A1 19981014; EP 0869802 A4 20011114; JP 2000502246 A 20000229

DOCDB simple family (application)

US 9618675 W 19961122; AU 1161497 A 19961122; CA 2238404 A 19961122; EP 96942785 A 19961122; JP 51988597 A 19961122