Global Patent Index - EP 0869960 B1

EP 0869960 B1 20020703 - PROCESS FOR THE RECOVERY OF AMPICILLIN

Title (en)

PROCESS FOR THE RECOVERY OF AMPICILLIN

Title (de)

VERFAHREN ZUR WINNUNG VON AMPICILLIN

Title (fr)

PROCEDE DE RECUPERATION D'AMPICILLINE

Publication

EP 0869960 B1 20020703 (EN)

Application

EP 96906103 A 19960325

Priority

  • BE 9500291 A 19950331
  • NL 9600128 W 19960325

Abstract (en)

[origin: WO9630376A1] Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is homogeneous at a pH between 7 and 8.5, is subjected to a pH lowering till a pH lower than 8.2 is reached, and the solid substance present is recovered. The process is in particular suitable to be applied to the reaction mixture which is obtained after the enzymatic acylation reaction of 6-APA with a phenylglycidine derivative as acylation agent. Pure ampicillin can thus be recovered in a simple way.

IPC 1-7

C07D 499/00; C12P 37/04

IPC 8 full level

C07D 499/00 (2006.01); C07D 499/18 (2006.01); C12P 37/04 (2006.01)

CPC (source: EP)

C07D 499/00 (2013.01); C12P 37/04 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB IE IT LI NL PT SE

DOCDB simple family (publication)

WO 9630376 A1 19961003; AT 220069 T 20020715; AU 4958296 A 19961016; BE 1009264 A3 19970107; CN 1103777 C 20030326; CN 1185157 A 19980617; CZ 307497 A3 19980114; DE 69622193 D1 20020808; DE 69622193 T2 20030320; EP 0869960 A1 19981014; EP 0869960 B1 20020703; ES 2179180 T3 20030116; IN 183010 B 19990821; JP H11502832 A 19990309; KR 100442040 B1 20050805; KR 19980703622 A 19981205; MX 9707550 A 19971129

DOCDB simple family (application)

NL 9600128 W 19960325; AT 96906103 T 19960325; AU 4958296 A 19960325; BE 9500291 A 19950331; CN 96194145 A 19960325; CZ 307497 A 19960325; DE 69622193 T 19960325; EP 96906103 A 19960325; ES 96906103 T 19960325; IN 483MA1996 A 19960326; JP 52920896 A 19960325; KR 19970707021 A 19970930; MX 9707550 A 19960325