EP 0869972 A1 19981014 - CHEMOKINE FROM NIDDM PANCREAS
Title (en)
CHEMOKINE FROM NIDDM PANCREAS
Title (de)
Chemokine aus einer NIDDM- Bauchspeicheldrüse
Title (fr)
CHEMOKINE ISSUE DU PANCREAS D'UN SUJET A DIABETE NON INSULINODEPENDANT SUCRE
Publication
Application
Priority
- US 9618398 W 19961115
- US 680995 P 19951115
- US 56633495 A 19951201
Abstract (en)
[origin: WO9718237A1] The present invention provides a polynucleotide (mcp-4) which identifies and encodes a novel monocyte chemotactic protein (MCP-4) which was expressed in cells of NIDDM pancreas. The present invention also provides for antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MCP-4; antibodies, antagonists and inhibitors which specifically bind MCP-4; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antagonists and inhibitors. The invention specifically provides for use of the polypeptide as a positive control in diagnostic assays which also allow identification of altered mcp-4 expression. These assays utilize diagnostic compositions designed from mcp-4 encoding or complementary polynucleotide sequences, including oligomers, and anti-MCP-4 antibodies.
IPC 1-7
C07K 14/52; A61K 38/19; C12Q 1/68; C12N 5/10; A61K 48/00; C07K 16/24
IPC 8 full level
G01N 33/53 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 31/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07K 14/52 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/10 (2017.12); A61P 31/00 (2017.12); A61P 37/00 (2017.12); A61P 43/00 (2017.12); C07K 14/523 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2799/021 (2013.01)
Citation (search report)
See references of WO 9718237A1
Designated contracting state (EPC)
BE DE ES FR GB IT NL
DOCDB simple family (publication)
WO 9718237 A1 19970522; AU 7735696 A 19970605; CA 2237998 A1 19970522; EP 0869972 A1 19981014; JP 2000500970 A 20000202
DOCDB simple family (application)
US 9618398 W 19961115; AU 7735696 A 19961115; CA 2237998 A 19961115; EP 96940487 A 19961115; JP 51912397 A 19961115