EP 0871436 A1 19981021 - USE OF Stat 6 SH2 DOMAIN SPECIFIC COMPOUNDS TO TREAT ALLERGIC REACTIONS
Title (en)
USE OF Stat 6 SH2 DOMAIN SPECIFIC COMPOUNDS TO TREAT ALLERGIC REACTIONS
Title (de)
VERWENDUNG VON STAT 6 SH2 DOMAINE SPEZIFISCHEN VERBINDUNGEN ZUR BEHANDLUNG ALLERGISCHER REAKTIONEN
Title (fr)
UTILISATION DE COMPOSES SPECIFIQUES DU DOMAINE Stat 6 SH2 POUR LE TRAITEMENT DES REACTIONS ALLERGIQUES
Publication
Application
Priority
- US 9611074 W 19960628
- US 49735795 A 19950630
- US 59871696 A 19960208
Abstract (en)
[origin: WO9702023A1] Invented is a method of treating allergic reactions in a subject which comprises administering to the subject a therapectically effective amount of a compound which binds to a human Stat 6 SH2 domain with a binding affinity greater than fifty-fold higher than the binding affinity with which the compound binds to a human Stat 5 SH2 domain, binds to a human hcp SH2 domain, a human Grb2 SH2 domain, a human SH-PTP2 SH2 domain and a human p85 SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such Stat 6 SH2 domain, and binds to a human src SH2 domain, a human lck SH2 domain and a human fyn SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such Stat 6 SH2 domain.
IPC 1-7
IPC 8 full level
C07D 237/14 (2006.01); A61K 31/00 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/195 (2006.01); A61K 31/40 (2006.01); A61K 31/437 (2006.01); A61K 31/4745 (2006.01); A61K 31/50 (2006.01); A61K 31/546 (2006.01); A61K 45/00 (2006.01); A61P 11/06 (2006.01); A61P 37/08 (2006.01); C07D 207/50 (2006.01); C07D 495/22 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/12 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/195 (2013.01); A61K 31/40 (2013.01); A61K 31/437 (2013.01); A61K 31/50 (2013.01); A61K 31/546 (2013.01); A61P 11/06 (2017.12); A61P 37/08 (2017.12)
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9702023 A1 19970123; AU 6480796 A 19970205; CA 2225668 A1 19970123; EP 0871436 A1 19981021; EP 0871436 A4 19991020; JP 2000514036 A 20001024
DOCDB simple family (application)
US 9611074 W 19960628; AU 6480796 A 19960628; CA 2225668 A 19960628; EP 96924322 A 19960628; JP 50523497 A 19960628