EP 0871455 A1 19981021 - IN VITRO GROWTH OF FUNCTIONAL ISLETS OF LANGERHANS AND IN VIVO USES THEREOF

Title (en)

IN VITRO GROWTH OF FUNCTIONAL ISLETS OF LANGERHANS AND IN VIVO USES THEREOF

Title (de)

IM-VITRO WACHSTUM VON FUNKTIONALEN LANGERHANSINSELN UND DEREN IN VIVO VERWENDUNG

Title (fr)

CROISSANCE IN VITRO D'ILOTS DE LANGERHANS FONCTIONNELS ET UTILISATIONS IN VIVO DE CES ILOTS

Publication

EP 0871455 A1 19981021 (EN)

Application

EP 96936866 A 19961023

Priority

US 9616952 W 19961023
US 54774695 A 19951025

Abstract (en)

[origin: WO9715310A1] The subject invention concerns new methods which make it possible, for the first time, to grow functional islets in in vitro cultures. The subject invention also concerns the use of the in vitro grown islet-like structures for implantation into a mammal for in vivo therapy of diabetes. The subject invention further concerns a process using the in vitro grown islet implants for growing an organ in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic tissue. The ability to grow these cells in vitro and organs in vivo opens up important new avenues for research and therapy relating to diabetes.

IPC 1-7

A61K 31/70; A61K 38/00; A61K 49/00; A01N 43/04; A01N 63/00; A01N 65/00; C12N 5/00; C12N 5/06; C12N 5/10; C12N 5/16; C12N 5/18

IPC 8 full level

A01K 67/027 (2006.01); A61K 31/00 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); C07K 14/725 (2006.01); C12N 5/074 (2010.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); A61K 35/12 (2015.01); A61K 48/00 (2006.01)

CPC (source: EP)

A61P 3/00 (2017.12); A61P 3/10 (2017.12); C12N 5/0678 (2013.01); A61K 35/12 (2013.01); A61K 48/00 (2013.01); C12N 2500/34 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9715310 A1 19970501; AU 739771 B2 20011018; AU 7468396 A 19970515; CA 2235509 A1 19970501; EP 0871455 A1 19981021; EP 0871455 A4 20030514; JP H11514877 A 19991221; MX 9803263 A 19980930

DOCDB simple family (application)

US 9616952 W 19961023; AU 7468396 A 19961023; CA 2235509 A 19961023; EP 96936866 A 19961023; JP 51673497 A 19961023; MX 9803263 A 19980424