Global Patent Index - EP 0871495 A4

EP 0871495 A4 2000-09-13 - REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS

Title (en)

REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS

Title (de)

RICHTUNGSÄNDERUNG DER ZELLULÄREN IMMUNITÄT DURCH REZEPTORCHIMÄREN

Title (fr)

REORIENTATION DE L'IMMUNITE CELLULAIRE AU MOYEN DE RECEPTEURS CHIMERIQUES

Publication

EP 0871495 A4 (EN)

Application

EP 96904498 A

Priority

  • US 9601056 W
  • US 39417695 A

Abstract (en)

[origin: WO9625953A1] Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal at least two chimeric receptors which trigger the specific recognition and destruction of an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. One of the expressed chimeric receptors includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular or transmembrane portion which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent; and the second chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular portion which is derived from CD28. Also disclosed are pairs of useful chimeric receptors, cells which express the chimeric receptors, and DNA encoding the chimeric receptors.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 48/00; C07K 14/705; C12N 5/00; C12N 5/10

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/14 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 37/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 14/735 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 5/00 (2006.01); C12N 5/06 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01)

CPC (invention and additional information)

C07K 14/7051 (2013.01); A61K 48/00 (2013.01); C07K 14/70503 (2013.01); C07K 14/70514 (2013.01); C07K 14/70535 (2013.01); C07K 16/28 (2013.01); C07K 2319/00 (2013.01); C12N 2799/023 (2013.01)

Citation (search report)

  • [E] WO 9626265 A1 19960829 - GEN HOSPITAL CORP [US]
  • [A] WO 9215322 A1 19920917 - GEN HOSPITAL CORP [US]
  • [AD] ROMEO C ET AL: "ACTIVATION OF IMMUNE SYSTEM EFFECTOR FUNCTION BY T-CELL OR FC RECEPTOR INTRACELLULAR DOMAINS", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,US,NEW YORK, NY, vol. 57, 1992, pages 117 - 125, XP000647674
  • See also references of WO 9625953A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9625953 A1 19960829; AT 297986 T 20050715; AU 4858896 A 19960911; AU 708339 B2 19990805; CA 2209300 A1 19960829; CA 2209300 C 20110628; CZ 295428 B6 20050817; CZ 9702599 A3 19980513; DE 69634855 D1 20050721; DE 69634855 T2 20060518; DK 0871495 T3 20051017; EP 0871495 A1 19981021; EP 0871495 A4 20000913; EP 0871495 B1 20050615; ES 2245456 T3 20060101; FI 119757 B 20090313; FI 973437 A0 19970821; FI 973437 A 19971016; HU 225688 B1 20070628; HU 9801873 A2 19981130; HU 9801873 A3 20000828; JP 4170390 B2 20081022; JP H11505409 A 19990521; NO 323632 B1 20070618; NO 973864 A 19971022; NO 973864 D0 19970822; NZ 302513 A 19991129; NZ 337002 A 20050729; PT 871495 E 20051031; RU 2167676 C2 20010527; ZA 9601477 B 19970203