EP 0871495 A4 20000913 - REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS
Title (en)
REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS
Title (de)
RICHTUNGSÄNDERUNG DER ZELLULÄREN IMMUNITÄT DURCH REZEPTORCHIMÄREN
Title (fr)
REORIENTATION DE L'IMMUNITE CELLULAIRE AU MOYEN DE RECEPTEURS CHIMERIQUES
Publication
Application
Priority
- US 9601056 W 19960125
- US 39417695 A 19950224
Abstract (en)
[origin: WO9625953A1] Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal at least two chimeric receptors which trigger the specific recognition and destruction of an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. One of the expressed chimeric receptors includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular or transmembrane portion which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent; and the second chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular portion which is derived from CD28. Also disclosed are pairs of useful chimeric receptors, cells which express the chimeric receptors, and DNA encoding the chimeric receptors.
IPC 1-7
IPC 8 full level
A61K 35/14 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 37/00 (2006.01); C07K 14/705 (2006.01); C12N 15/09 (2006.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 14/735 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 5/00 (2006.01); C12N 5/07 (2010.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01)
CPC (source: EP KR)
A61K 48/00 (2013.01 - EP); A61P 37/00 (2018.01 - EP); C07K 14/705 (2013.01 - KR); C07K 14/70503 (2013.01 - EP); C07K 14/7051 (2013.01 - EP); C07K 14/70514 (2013.01 - EP); C07K 14/70535 (2013.01 - EP); C07K 16/28 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); C12N 2799/023 (2013.01 - EP)
Citation (search report)
- [E] WO 9626265 A1 19960829 - GEN HOSPITAL CORP [US]
- [A] WO 9215322 A1 19920917 - GEN HOSPITAL CORP [US]
- [AD] ROMEO C ET AL: "ACTIVATION OF IMMUNE SYSTEM EFFECTOR FUNCTION BY T-CELL OR FC RECEPTOR INTRACELLULAR DOMAINS", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,US,NEW YORK, NY, vol. 57, 1992, pages 117 - 125, XP000647674
- See also references of WO 9625953A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9625953 A1 19960829; AT E297986 T1 20050715; AU 4858896 A 19960911; AU 708339 B2 19990805; CA 2209300 A1 19960829; CA 2209300 C 20110628; CZ 259997 A3 19980513; CZ 295428 B6 20050817; DE 69634855 D1 20050721; DE 69634855 T2 20060518; DK 0871495 T3 20051017; EP 0871495 A1 19981021; EP 0871495 A4 20000913; EP 0871495 B1 20050615; ES 2245456 T3 20060101; FI 119757 B 20090313; FI 973437 A0 19970821; FI 973437 A 19971016; HU 225688 B1 20070628; HU P9801873 A2 19981130; HU P9801873 A3 20000828; JP 4170390 B2 20081022; JP H11505409 A 19990521; KR 100490099 B1 20051128; KR 19980702450 A 19980715; NO 323632 B1 20070618; NO 973864 D0 19970822; NO 973864 L 19971022; NZ 302513 A 19991129; NZ 337002 A 20050729; PT 871495 E 20051031; RU 2167676 C2 20010527; ZA 961477 B 19970203
DOCDB simple family (application)
US 9601056 W 19960125; AT 96904498 T 19960125; AU 4858896 A 19960125; CA 2209300 A 19960125; CZ 259997 A 19960125; DE 69634855 T 19960125; DK 96904498 T 19960125; EP 96904498 A 19960125; ES 96904498 T 19960125; FI 973437 A 19970821; HU P9801873 A 19960125; JP 52568596 A 19960125; KR 19970705850 A 19970823; NO 973864 A 19970822; NZ 30251396 A 19960125; NZ 33700296 A 19960125; PT 96904498 T 19960125; RU 97115769 A 19960125; ZA 961477 A 19960223