Title (en)

A 12-KDA PROTEIN DERIVED FROM M. TUBERCULOSIS USEFUL FOR TREATMENT OF AUTOIMMUNE DISEASES

Title (de)

EIN 12 KDA PROTEIN AUS M. TUBERCULOSIS, WELCHES NÜTZLICH ZUR BEHANDLUNG VON AUTOIMMUNKRANKHEITEN IST

Title (fr)

PROTEINE DE 12 KDA DERIVEE DE M. TUBERCULOSIS ET EFFICACE POUR LE TRAITEMENT DE MALADIES AUTO-IMMUNES

Publication

EP 0871660 A4 20000823 (EN)

Application

EP 95943854 A 19951204

Priority

• IL 11186594 A 19941204
• US 9516444 W 19951204

Abstract (en)

[origin: WO9617864A1] The invention provides a 12-kDa PPD protein isolated and purified from the purified protein derivative (PPD), the major fraction of Mycobacterium tuberculosis that protects mice against the induction of experimental autoimmune encephalomyelitis (EAE), and salts, functional derivatives, analogs and active fractions thereof, and pharmaceutical compositions comprising them for the treatment of autoimmune diseases.

IPC 1-7

C07K 14/35; A61K 38/03

IPC 8 full level

C07K 14/35 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/35 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

• [E] WO 9616083 A1 19960530 - ITALFARMACO SPA [IT], et al
• [X] SHINNICK T M ET AL.: "Isolation and restriction site maps of the genes encoding five Mycobycterium tuberculosis proteins", INFECTION AND IMMUNITY, vol. 55, no. 7, July 1987 (1987-07-01), pages 1718 - 1721, XP002140325
• [X] KONG T H ET AL.: "Mycobacterium tuberculosis expresses two chaperonin-60 homologs", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 90, April 1993 (1993-04-01), pages 2608 - 2612, XP002140326
• [X] DATABASE WPI Week 9032, Derwent World Patents Index; AN 1990-242951, XP002140327
• See references of WO 9617864A1

Designated contracting state (EPC)

CH DE DK FR GB IT LI SE

DOCDB simple family (publication)

WO 9617864 A1 19960613; EP 0871660 A1 19981021; EP 0871660 A4 20000823; IL 111865 A0 19950315; IL 111865 A 20050320

DOCDB simple family (application)

US 9516444 W 19951204; EP 95943854 A 19951204; IL 11186594 A 19941204