EP 0871711 A1 19981021 - COMPOSITIONS AND METHODS FOR SITE-DIRECTED INTEGRATION INTO DNA
Title (en)
COMPOSITIONS AND METHODS FOR SITE-DIRECTED INTEGRATION INTO DNA
Title (de)
ZUSAMMENSETZUNGEN UND METHODEN FÜR DIE ORTSSPEZIFISCHE INTEGRATION IN DNS
Title (fr)
COMPOSITIONS ET PROCEDES D'INTEGRATION DIRECTIONNELLE DANS DE L'ADN
Publication
Application
Priority
- US 9619277 W 19961127
- US 826395 P 19951201
Abstract (en)
[origin: WO9720038A1] The present invention provides fusion proteins capable of integrating a donor DNA molecule into a target DNA molecule at or near a target nucleotide sequence. The fusion proteins comprise a retroviral integrase catalytic domain COOH-terminally coupled to a DNA binding protein domain having binding specificity for the target nucleotide sequence. Nucleic acids encoding same; vectors, expression systems, and host cells carrying nucleic acids encoding said fusion proteins; and methods of integrating a donor DNA molecule at or near a specific site on a target DNA molecule are provided. The integrating may result in a gene encoding a therapeutic to be introduced via gene therapy, or may result in an oncogene being inactivated, for example.
IPC 1-7
C12N 9/00; C07H 19/00; C07H 21/00; C07K 1/00; C07K 14/00; C07K 17/00
IPC 8 full level
C07K 14/47 (2006.01); C12N 9/22 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C12N 9/22 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9720038A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9720038 A1 19970605; AU 1408597 A 19970619; EP 0871711 A1 19981021
DOCDB simple family (application)
US 9619277 W 19961127; AU 1408597 A 19961127; EP 96944223 A 19961127