EP 0873338 A1 19981028 - QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS
Title (en)
QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS
Title (de)
CHINOLINDERIVATE ALS TYPE IV PHOSPHODIESTERASE INHIBITOREN
Title (fr)
DERIVES QUINOLINES EN TANT QU'INHIBITEURS DES PHOSPHODIESTERASES DE TYPE IV
Publication
Application
Priority
- EP 9604978 W 19961113
- GB 9523267 A 19951114
Abstract (en)
[origin: WO9718208A1] 8-(Benzo[c]thiadiazolyl, benzo[c]furazanyl, or 2-methyl-2H-benzo[d]triazolyl)-quinolines, in free or N-oxide or acid addition or ammonium salt form, are novel and found to be useful as pharmaceuticals, e.g., as PDEIV inhibitors, for example in the treatment of asthma. Novel methods of treatment using the compounds, processes for making the compounds, and pharmaceutical compositions comprising the compounds are also provided. For example, compounds of formula (1), wherein X is -O-, -S-, or -N(CH3)-, R1 is hydrogen or (C1-4)alkyl, and R2 is (C1-4)alkyl or pyridyl, in free or N-oxide or pharmaceutically acceptable acid addition or ammonium salt form.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61P 11/00 (2006.01); C07D 401/04 (2006.01); A61P 25/08 (2006.01); A61P 25/16 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP KR)
A61P 11/00 (2018.01 - EP); A61P 25/08 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 401/14 (2013.01 - EP KR); C07D 413/14 (2013.01 - EP KR); C07D 417/14 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9718208 A1 19970522; AU 7570996 A 19970605; BR 9611504 A 19990302; CA 2235126 A1 19970522; CN 1202170 A 19981216; CO 4770973 A1 19990430; CZ 149498 A3 19980812; EP 0873338 A1 19981028; GB 9523267 D0 19960117; HU P9903492 A2 20000728; HU P9903492 A3 20000828; JP H11515000 A 19991221; KR 19990067574 A 19990825; MX 9803839 A 19980930; PE 17598 A1 19980406; PL 326636 A1 19981012; SK 63998 A3 19981007; TR 199800851 T2 19980821
DOCDB simple family (application)
EP 9604978 W 19961113; AU 7570996 A 19961113; BR 9611504 A 19961113; CA 2235126 A 19961113; CN 96198305 A 19961113; CO 96059775 A 19961113; CZ 149498 A 19961113; EP 96938196 A 19961113; GB 9523267 A 19951114; HU P9903492 A 19961113; JP 51531397 A 19961113; KR 19980703597 A 19980514; MX 9803839 A 19980514; PE 00081096 A 19961112; PL 32663696 A 19961113; SK 63998 A 19961113; TR 9800851 T 19961113