EP 0873352 A1 19981028 - PROCESS FOR PREPARATION OF 9,11-g(b)-EPOXIDE STEROIDS
Title (en)
PROCESS FOR PREPARATION OF 9,11-g(b)-EPOXIDE STEROIDS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 9,11 BETA-EPOXIDE STEROIDE
Title (fr)
PROCEDES DE PREPARATION DE STEROIDES 9,11-g(b)-EPOXIDE
Publication
Application
Priority
- US 9619600 W 19961218
- US 57556295 A 19951220
Abstract (en)
[origin: WO9722616A1] Disclosed is a process for producing the epoxy steroid (1.0) wherein R<1> is selected from H, -OH, or C1, and R<2> is selected from hydrogen or lower alkyl. The process comprises reacting the triene of Formula (2.0) with a brominating or chlorinating agent in DMF containing a catalytic amount of 70 % HC1O4, at a temperature of about 0 to about +40 DEG C to produce the corresponding bromoformate (3.0) or chloroformate (3.0A) wherein when R<1> is H then R<3> is H; and when R<1> is -OH then R<3> is a suitably protected -OH group; and when R<1> is C1 then R<3> is C1. The bromoformate or chloroformate is then reacted, at a temperature of about -20 to about +10 DEG C, with a strong base in an organic solvent mixture comprising: (a) THF or CH2C12 and (b) a C1 to C6 alkanol or acetonitrile, to produce the epoxy steroid (1.0).
IPC 1-7
IPC 8 full level
C07J 5/00 (2006.01); C07J 7/00 (2006.01); C07J 71/00 (2006.01)
CPC (source: EP KR)
C07J 5/00 (2013.01 - KR); C07J 5/0076 (2013.01 - EP); C07J 7/00 (2013.01 - KR); C07J 7/0085 (2013.01 - EP); C07J 71/00 (2013.01 - KR); C07J 71/0015 (2013.01 - EP)
Citation (search report)
See references of WO 9722616A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9722616 A1 19970626; AU 1331097 A 19970714; BR 9612064 A 19990223; CN 1209138 A 19990224; CZ 191398 A3 19981111; EP 0873352 A1 19981028; IL 125004 A0 19990126; JP 2000502102 A 20000222; KR 20000064495 A 20001106; MX 9804957 A 19980930; NO 982877 D0 19980619; NO 982877 L 19980820; PL 327141 A1 19981123
DOCDB simple family (application)
US 9619600 W 19961218; AU 1331097 A 19961218; BR 9612064 A 19961218; CN 96180071 A 19961218; CZ 191398 A 19961218; EP 96944777 A 19961218; IL 12500496 A 19961218; JP 52287297 A 19961218; KR 19980704706 A 19980620; MX 9804957 A 19980619; NO 982877 A 19980619; PL 32714196 A 19961218