EP 0876381 A1 19981111 - IFOSFAMIDE, ANALOGUES THEREOF AND THEIR PREPARATION
Title (en)
IFOSFAMIDE, ANALOGUES THEREOF AND THEIR PREPARATION
Title (de)
IFOSFAMID,ANALOGEDAVON UND IHRE HERSTELLUNG
Title (fr)
IFOSFAMIDE, ANALOGUES DE LADITE SUBSTANCE ET LEUR PREPARATION
Publication
Application
Priority
- GB 9603157 W 19961219
- GB 9525891 A 19951219
- GB 9602519 A 19960208
Abstract (en)
[origin: WO9722614A1] A compound of formula (I) wherein R<1> and R<2> are each (CH2)mX, R<3> is H, each X is Cl or Br and m is 2 or 3, in combination with less than 0.5 % w/w of the corresponding compound wherein R<1> is (CH2)mH. Such compounds can be prepared by (i) the reaction of a Bronsted acid or a Lewis acid with NaBH4 in an organic solvent, and (ii) adding the resultant solution to a solution of a corresponding compound wherein one of R<1> and R<2> is CO(CH2)nX and the other is CO(CH2)nX or (CH2)mX, wherein n = m-1. Such compounds can also be prepared, in optically-enriched form, starting from an optically-enriched trihaloiminophosphorane of the formula R*N = Phal3 wherein NR* is a chiral moiety derivable from a chiral amine or chiral sulphonamide of the formula R*NH2, which can be cyclisable with HO(CH2)3NHR.
IPC 1-7
IPC 8 full level
C07F 9/06 (2006.01); C07F 9/6584 (2006.01)
CPC (source: EP)
C07F 9/065 (2013.01); C07F 9/65846 (2013.01)
Citation (search report)
See references of WO 9722614A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9722614 A1 19970626; AU 1164597 A 19970714; EP 0876381 A1 19981111
DOCDB simple family (application)
GB 9603157 W 19961219; AU 1164597 A 19961219; EP 96942509 A 19961219