Global Patent Index - EP 0876480 A4

EP 0876480 A4 19991020 - ANIMALS WITH TARGETED GENE DELETION

Title (en)

ANIMALS WITH TARGETED GENE DELETION

Title (de)

TIERE MIT GEZIELTER GENDELETION

Title (fr)

ANIMAUX A DELETION CIBLEE DE GENE

Publication

EP 0876480 A4 19991020 (EN)

Application

EP 96936753 A 19961018

Priority

  • US 9616807 W 19961018
  • US 575895 P 19951020

Abstract (en)

[origin: WO9714791A1] A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for the testing of therapeutic agents for the treatment or prevention of diseases which include autoimmune diseases, allergy, asthma and malignant disease.

IPC 1-7

C12N 15/00

IPC 8 full level

C12N 9/12 (2006.01); C12N 15/85 (2006.01)

CPC (source: EP)

A01K 67/0276 (2013.01); C12N 9/1205 (2013.01); C12N 15/8509 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0325 (2013.01)

Citation (search report)

  • [PX] HIBBS, M.L. ET AL.: "Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease", CELL, vol. 83, no. 2, 20 October 1995 (1995-10-20), pages 301 - 311, XP002101398
  • [PX] WANG, J. ET AL.: "Altered antigen receptor signaling and impaired fas-mediated apoptosis of B cells in lyn-deficient mice", JOURNAL OF EXPERIMENTAL MEDECINE, vol. 184, no. 3, 1 September 1996 (1996-09-01), pages 831 - 838, XP002101399
  • [PX] NISHIZUMI, H. ET AL.: "Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice", IMMUNITY, vol. 3, no. 5, November 1995 (1995-11-01), pages 549 - 560, XP002101400
  • [XY] TAKATA, M. ET AL.: "Tyrosine kinsases lyn and syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways", THE EMBO JOURNAL, vol. 13, 1994, pages 1341 - 1349, XP002101401
  • [Y] MOLINA, T.J. ET AL.: "Profound block in thymocyte development in mice lacking p56lck", NATURE, vol. 357, 14 May 1992 (1992-05-14), pages 161 - 164, XP002101402
  • [Y] STEIN, P.L. ET AL.: "pp59fyn-mutant mice display differential signaling in thymocytes and peripheral T cell.", CELL, vol. 70, 1992, pages 741 - 750, XP002101403
  • [AD] HIBBS, M.L. ET AL.: "Identification of a duplication of the mouse lyn gene", GENE, vol. 156, no. 2, 24 April 1995 (1995-04-24), pages 175 - 181, XP004042352
  • [A] TORIGOE, T. ET AL.: "Regulation of src-family protein tyrosine kinases by interleukins, IL-2 and IL-3", LEUKEMIA, vol. 6, no. Suppl. 3, 1992, pages 94S - 97S, XP002101404
  • [A] COREY, S.ET AL.: "Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3-OH-Kinase and src-related tyrosine kinase(s) in human myeloid derived cells", THE EMBO JOURNAL, vol. 12, no. 7, July 1993 (1993-07-01), pages 2681 - 2690, XP002101405
  • [A] KEFALAS, P. ET AL.: "Signalling by the p60c-src family of protein tyrosine kinases", INT.J.BIOCHEM.CELL.BIOL, vol. 27, no. 6, June 1995 (1995-06-01), pages 551 - 563, XP002101406
  • See references of WO 9714791A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9714791 A1 19970424; EP 0876480 A1 19981111; EP 0876480 A4 19991020

DOCDB simple family (application)

US 9616807 W 19961018; EP 96936753 A 19961018