EP 0877608 A1 19981118 - SENSITIZATION OF HER2/neu OVER-EXPRESSING CANCER CELLS TO CHEMOTHERAPEUTIC DRUGS
Title (en)
SENSITIZATION OF HER2/neu OVER-EXPRESSING CANCER CELLS TO CHEMOTHERAPEUTIC DRUGS
Title (de)
SENSIBILISIERUNG VON HER2/NEU ÜBEREXPRIMIERENDEN KREBSZELLEN FÜR CHEMOTHERAPEUTISCHE MEDIKAMENTE
Title (fr)
SENSIBILISATION AUX SUBSTANCES CHIMIOTHERAPEUTIQUES DES CELLULES CANCEREUSES SUREXPRIMANT HER2/neu
Publication
Application
Priority
- US 9701686 W 19970131
- US 1087596 P 19960131
Abstract (en)
[origin: WO9727848A1] The present invention relates to methods for the inhibition of the gene product of the neu oncogene, p185neu tyrosine kinase. Over-expression of the neu oncogene leads to chemoresistance. The methods disclosed involve the novel use of emodin in combination with chemotherapeutic drugs to treat carcinoma. Furthermore, emodin surprisingly potentiates the antineoplastic effects of the chemotherapeutic agents. The inventors propose that emodin sensitizes cancer cells such that they become amenable to treatment by chemotherapeutic drugs.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/135 (2006.01); A61K 31/136 (2006.01); A61K 31/15 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/19 (2006.01); A61K 31/192 (2006.01); A61K 31/70 (2006.01); A61K 33/24 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/122 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
See references of WO 9727848A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9727848 A1 19970807; AU 1854597 A 19970822; CA 2245165 A1 19970807; EP 0877608 A1 19981118; JP 2000504020 A 20000404
DOCDB simple family (application)
US 9701686 W 19970131; AU 1854597 A 19970131; CA 2245165 A 19970131; EP 97904188 A 19970131; JP 52788097 A 19970131