EP 0877816 A1 19981118 - EXPRESSION OF GROUP B NEISSERIA MENINGITIDIS OUTER MEMBRANE (MB3) PROTEIN FROM YEAST AND VACCINES
Title (en)
EXPRESSION OF GROUP B NEISSERIA MENINGITIDIS OUTER MEMBRANE (MB3) PROTEIN FROM YEAST AND VACCINES
Title (de)
Expression eines Gruppe-B-Proteins der äusseren Membran von Neisseria meningitidis (MB3) in Hefe und Vakzine
Title (fr)
EXPRESSION DE LA PROTEINE DE LA MEMBRANE EXTERIEURE DE NEISSERIA MENINGITIDIS DU GROUPE B (MB3) A PARTIR DE LEVURES ET DE VACCINS
Publication
Application
Priority
- US 9701687 W 19970131
- US 1097296 P 19960201
- US 2044096 P 19960613
Abstract (en)
[origin: WO9728273A1] The present invention relates, in general, to a method for obtaining the outer membrane protein meningococcal group B porin proteins, in particular MB3, and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in yeast. The invention also relates to a method of high level expression of the above-mentioned proteins wherein the rate of protein expression is enhanced by substituting a nucleotide sequence for the 5' region of the gene encoding said protein wherein the sequence has been optimized for yeast codon usage. The invention also relates to a vaccine comprising group A meningococcal polysaccharide (GAMP), group B meningococcal polysaccharide (GBMP) and group C meningococcal polysaccharide (GCMP) antigens, together with a pharmaceutically acceptable carrier. The invention also relates to a method of inducing an immune response in a mammal, comprising administering the above-mentioned vaccine to a mammal in an amount sufficient to induce an immune response.
IPC 1-7
C12P 21/04; C12P 21/06; C12N 15/00; C12N 1/14; A23J 1/00; C07K 1/00; C07H 21/04; A61K 39/00; A61K 39/385
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/095 (2006.01); A61K 39/385 (2006.01); A61K 47/48 (2006.01); A61P 31/04 (2006.01); C07K 14/22 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12P 21/02 (2006.01); C12N 15/09 (2006.01); C12P 21/04 (2006.01)
CPC (source: EP KR)
A61K 47/646 (2017.08 - EP); A61P 31/04 (2018.01 - EP); C07K 14/22 (2013.01 - EP); C12N 1/14 (2013.01 - KR); C12N 15/00 (2013.01 - KR); C12P 21/02 (2013.01 - KR); A61K 39/00 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB IE IT LI LU NL SE
DOCDB simple family (publication)
WO 9728273 A1 19970807; AU 2115897 A 19970822; EP 0877816 A1 19981118; HU P9901039 A2 19990728; IL 125420 A0 19990312; JP 2001508758 A 20010703; KR 19990082265 A 19991125; NO 983474 D0 19980728; NO 983474 L 19980930; PL 328096 A1 19990104
DOCDB simple family (application)
US 9701687 W 19970131; AU 2115897 A 19970131; EP 97906470 A 19970131; HU P9901039 A 19970131; IL 12542097 A 19970131; JP 52788197 A 19970131; KR 19980705994 A 19980731; NO 983474 A 19980728; PL 32809697 A 19970131