EP 0879227 A1 19981125 - TYROSIN-DERIVATE AS ALPHA-V-INTEGRIN INHIBITORS
Title (en)
TYROSIN-DERIVATE AS ALPHA-V-INTEGRIN INHIBITORS
Title (de)
TYROSIN-DERIVATE ALS ALPHA-V-INTEGRIN-INHIBITOREN
Title (fr)
DERIVES DE TYROSINE UTILISES COMME INHIBITEURS D'ALPHA-V-INTEGRINE
Publication
Application
Priority
- DE 19548709 A 19951223
- EP 9605646 W 19961216
Abstract (en)
[origin: DE19548709A1] Disclosed are compounds of formula (I) in which X represents alkylene with 1-6 C atoms or 1,4-piperidyl; Y is absent or represents O, CONH or -CC-; R<1> represents H, CN, N3, NH2, H2N-C(=NH) or H2N-(C=NH)-NH (the primary amino groups can also be provided with conventional amino protective groups); R<2>, R<3> each independently of one another represent H, A, A-SO2-, Ar-SO2, campher-10-SO2-, COOA or a conventional amino protective group; A, R<4> each independently of one another represent H or alkyl with 1-10 C atoms; and Ar represents phenyl or benzyl which is unsubstituted or single-substituted with CH3. Also disclosed are the physiologically tolerable salts of these compounds. The compounds and salts thereof can be used as alpha v-integrin inhibitors, in particular for treating tumours, osteoporoses, osteolytic disorders and for suppressing angiogenesis.
IPC 1-7
C07C 311/06; A61K 31/195; C07C 247/04; C07C 257/14; C07C 271/22; C07C 279/08; C07C 311/10; C07C 311/13; C07C 311/14; C07C 311/19; C07D 211/62
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/195 (2006.01); A61K 31/445 (2006.01); A61K 31/4465 (2006.01); A61P 5/24 (2006.01); A61P 19/00 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 271/22 (2006.01); C07C 271/28 (2006.01); C07D 211/46 (2006.01); C07C 279/08 (2006.01); C07C 311/06 (2006.01); C07C 311/10 (2006.01); C07C 311/13 (2006.01); C07C 311/14 (2006.01); C07C 311/19 (2006.01); C07D 211/62 (2006.01)
CPC (source: EP KR)
A61K 31/195 (2013.01 - KR); A61P 5/24 (2018.01 - EP); A61P 19/00 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 247/04 (2013.01 - KR); C07C 271/28 (2013.01 - EP); C07C 279/08 (2013.01 - EP); C07C 311/06 (2013.01 - EP KR); C07C 311/14 (2013.01 - EP); C07C 311/19 (2013.01 - EP); C07D 211/62 (2013.01 - EP KR); Y02P 20/55 (2015.11 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9723451 A1 19970703; AU 1301697 A 19970717; BR 9612201 A 19990713; CA 2241149 A1 19970703; CZ 195198 A3 19981111; DE 19548709 A1 19970703; EP 0879227 A1 19981125; HU P9903716 A2 20000328; JP 2000502664 A 20000307; KR 19990076676 A 19991015; MX 9804971 A 19980930; NO 982907 D0 19980622; NO 982907 L 19980622; PL 327185 A1 19981123; SK 78398 A3 19981104; ZA 9610725 B 19970626
DOCDB simple family (application)
EP 9605646 W 19961216; AU 1301697 A 19961216; BR 9612201 A 19961216; CA 2241149 A 19961216; CZ 195198 A 19961216; DE 19548709 A 19951223; EP 96944578 A 19961216; HU P9903716 A 19961216; JP 52328297 A 19961216; KR 19980704788 A 19980622; MX 9804971 A 19980619; NO 982907 A 19980622; PL 32718596 A 19961216; SK 78398 A 19961216; ZA 9610725 A 19961219