EP 0879288 A1 19981125 - VARIANTS OF THYMIDINE KINASE, RELATED NUCLEIC ACIDS SEQUENCES AND THEIR USE IN GENIC THERAPY

Title (en)

VARIANTS OF THYMIDINE KINASE, RELATED NUCLEIC ACIDS SEQUENCES AND THEIR USE IN GENIC THERAPY

Title (de)

VARIANTEN DER THYMIDINKINASE, DIESBEZÜGLICHE NUKLEINSÄURESEQUENZEN UND DEREN VERWENDUNG IN DER GENTHERAPIE

Title (fr)

VARIANTS DE LA THYMIDINE KINASE, SEQUENCES D'ACIDES NUCLEIQUES CORRESPONDANTES ET LEUR UTILISATION EN THERAPIE GENIQUE

Publication

EP 0879288 A1 19981125 (FR)

Application

EP 97902417 A 19970131

Priority

FR 9700193 W 19970131
FR 9601603 A 19960209
FR 9609709 A 19960801

Abstract (en)

[origin: WO9729196A1] The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their uses in genic therapy.

IPC 1-7

C12N 15/54; C12N 9/12; A61K 38/45

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); C12N 15/09 (2006.01); A61K 31/711 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 9/12 (2006.01); C12N 15/38 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP KR US)

A61K 38/45 (2013.01 - KR); A61P 35/00 (2018.01 - EP); C12N 9/12 (2013.01 - KR); C12N 9/1211 (2013.01 - EP US); C12N 15/52 (2013.01 - KR); A01K 2217/05 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9729196 A1 19970814; AU 1606897 A 19970828; AU 720936 B2 20000615; BR 9707483 A 19990406; CZ 247998 A3 19981111; CZ 294497 B6 20050112; EP 0879288 A1 19981125; HU P9902571 A2 19991129; HU P9902571 A3 20020128; IL 125597 A0 19990312; JP 2000505288 A 20000509; KR 19990082124 A 19991115; NO 983449 D0 19980727; NO 983449 L 19980727; SK 107998 A3 19990111; US 2002102247 A1 20020801; US 6207150 B1 20010327

DOCDB simple family (application)

FR 9700193 W 19970131; AU 1606897 A 19970131; BR 9707483 A 19970131; CZ 247998 A 19970131; EP 97902417 A 19970131; HU P9902571 A 19970131; IL 12559797 A 19970131; JP 52820897 A 19970131; KR 19980705846 A 19980729; NO 983449 A 19980727; SK 107998 A 19970131; US 12509998 A 19980806; US 73435700 A 20001212