EP 0880361 A1 19981202 - IMMUNOGENIC DETOXIFIED MUTANTS OF CHOLERA TOXIN
Title (en)
IMMUNOGENIC DETOXIFIED MUTANTS OF CHOLERA TOXIN
Title (de)
IMMUNOGENE ENTOXIFIZIERTE MUTANTEN DES CHOLERATOXINS
Title (fr)
MUTANTS DETOXIQUES ET IMMUNOGENES DE TOXINE DU CHOLERA
Publication
Application
Priority
- GB 9603314 A 19960216
- IB 9700183 W 19970217
Abstract (en)
[origin: WO9729771A1] An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof in which at least one amino acid is substituted with another amino acid characterized in that, in purified form, the immunogenic detoxified protein exhibits a residual toxicity greater than 10000 fold lower than its naturally occurring counterpart. In the described embodiment, the amino acid at, or in a position corresponding to Pro-106 is replaced with another amino acid. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae and is produced by recombinant DNA means by site-directed mutagenesis.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/106 (2006.01); C07K 14/18 (2006.01); C07K 14/28 (2006.01); C07K 16/12 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12P 21/00 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
C07K 14/28 (2013.01 - EP); C07K 16/1239 (2013.01 - EP); A61K 39/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9729771 A1 19970821; CA 2244800 A1 19970821; EP 0880361 A1 19981202; GB 9603314 D0 19960417; JP 2000506002 A 20000523
DOCDB simple family (application)
IB 9700183 W 19970217; CA 2244800 A 19970217; EP 97902552 A 19970217; GB 9603314 A 19960216; JP 52915397 A 19970217