EP 0880532 A4 19990609 - NON-NUCLEOTIDE PHOSPHOROUS ESTER OLIGOMERS
Title (en)
NON-NUCLEOTIDE PHOSPHOROUS ESTER OLIGOMERS
Title (de)
NICHT-NUKLEOTIDE PHOPHORESTER-OLIGOMERE
Title (fr)
OLIGOMERES D'ESTER PHOSPHOREUX NON NUCLEOTIDIQUES
Publication
Application
Priority
- US 9701060 W 19970122
- US 59526496 A 19960201
Abstract (en)
[origin: WO9728168A1] A phosphorus ester oligomer having structure (I) wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B1 and B2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R1 is independently selected from the group consisting of a condensation product of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether, a purine or pyrimidine substituted 1,2-diol or a disubstituted heterocycle; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality; (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least one. Preferred R1 moieties include condensation products of heterocyclic diols, alicyclic diols, and polycyclic diols. Also the non-nucleotide monomers thereof, combinatorial library mixtures of the oligomers and the use of the oligomers as selective target-binding compounds.
IPC 1-7
C07F 9/58; C07F 9/6509; C07F 9/6512; C07F 9/6539; C07F 9/6561
IPC 8 full level
C07F 9/08 (2006.01); A61K 31/66 (2006.01); A61K 31/661 (2006.01); A61K 31/6615 (2006.01); C07F 9/141 (2006.01); C07F 9/143 (2006.01); C07F 9/145 (2006.01); C07F 9/24 (2006.01); C07F 9/572 (2006.01); C07F 9/58 (2006.01); C07F 9/6506 (2006.01); C07F 9/6509 (2006.01); C07F 9/6512 (2006.01); C07F 9/6539 (2006.01); C07F 9/655 (2006.01); C07F 9/6561 (2006.01); C07B 61/00 (2006.01)
CPC (source: EP)
C07F 9/1411 (2013.01); C07F 9/143 (2013.01); C07F 9/145 (2013.01); C07F 9/2408 (2013.01); C07F 9/2416 (2013.01); C07F 9/242 (2013.01); C07F 9/5728 (2013.01); C07F 9/58 (2013.01); C07F 9/6506 (2013.01); C07F 9/650952 (2013.01); C07F 9/6539 (2013.01); C07F 9/65515 (2013.01); C07F 9/6561 (2013.01); C07F 9/65616 (2013.01); C40B 40/00 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
- [DA] WO 9304204 A1 19930304 - ISIS PHARMACEUTICALS INC [US]
- [A] WO 9523160 A1 19950831 - ISIS PHARMACEUTICALS INC [US], et al
- [PX] WO 9622297 A1 19960725 - PHARMAGENICS INC [US]
- [DA] FONTANEL M.L.: "Sterical recognition by T4 polynucleotide kinase of non-nucleosidic moieties 5'-attached to oligonucleotides", NUCLEIC ACIDS RESEARCH., vol. 22, no. 11, 1994, OXFORD GB, pages 2022 - 2027, XP002098767
- [PX] FATHI R.: "Synthesis and properties of combinatorial libraries of phosphoramidates", JOURNAL OF ORGANIC CHEMISTRY., vol. 61, no. 16, 1996, EASTON US, pages 5600 - 5609, XP002055252
- See references of WO 9728168A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9728168 A1 19970807; AU 1753297 A 19970822; EP 0880532 A1 19981202; EP 0880532 A4 19990609; JP 2000506513 A 20000530
DOCDB simple family (application)
US 9701060 W 19970122; AU 1753297 A 19970122; EP 97933585 A 19970122; JP 52771897 A 19970122