EP 0880591 A1 19981202 - THROMBIN MUTEINS AS ANTIDOTES FOR THROMBIN INHIBITORS
Title (en)
THROMBIN MUTEINS AS ANTIDOTES FOR THROMBIN INHIBITORS
Title (de)
THROMBINMUTEINE ALS ANTIDOT FÜR THROMBININHIBITOREN
Title (fr)
MUTEINES DE THROMBINE S'UTILISANT COMME ANTIDOTE D'INHIBITEURS DE THROMBINE
Publication
Application
Priority
- DE 19605126 A 19960212
- EP 9700612 W 19970211
Abstract (en)
[origin: US6060300A] PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/00 (2006.01); A61K 38/00 (2006.01); A61K 38/46 (2006.01); A61P 7/00 (2006.01); A61P 7/04 (2006.01); C07K 14/47 (2006.01); C12N 9/74 (2006.01); C12N 15/00 (2006.01); C12N 15/57 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP KR US)
A61P 7/00 (2017.12 - EP); A61P 7/04 (2017.12 - EP); C12N 9/6429 (2013.01 - EP KR US); C12N 15/52 (2013.01 - KR); C12Y 304/21005 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9729198A1
Designated contracting state (EPC)
AT BE CH DE ES FI FR GB IT LI NL SE
DOCDB simple family (publication)
US 6060300 A 20000509; AR 005797 A1 19990714; AU 1768497 A 19970828; BR 9707280 A 19990720; CA 2245546 A1 19970814; CN 1211280 A 19990317; CO 4600682 A1 19980508; CZ 247798 A3 19990317; DE 19605126 A1 19970814; EP 0880591 A1 19981202; HR P970077 A2 19980430; HU P9900574 A2 19990628; IL 125077 A0 19990126; JP H11512621 A 19991102; KR 19990082479 A 19991125; NO 983677 D0 19980811; NO 983677 L 19980811; WO 9729198 A1 19970814; ZA 971107 B 19980811
DOCDB simple family (application)
US 11770898 A 19980804; AR P970100548 A 19970212; AU 1768497 A 19970211; BR 9707280 A 19970211; CA 2245546 A 19970211; CN 97192210 A 19970211; CO 97006960 A 19970211; CZ 247798 A 19970211; DE 19605126 A 19960212; EP 9700612 W 19970211; EP 97903254 A 19970211; HR P970077 A 19970211; HU P9900574 A 19970211; IL 12507797 A 19970211; JP 52817397 A 19970211; KR 19980706212 A 19980811; NO 983677 A 19980811; ZA 971107 A 19970211