EP 0880701 A1 19981202 - METHODS OF ASSESSING MHC CLASS I EXPRESSION AND PROTEINS CAPABLE OF MODULATING CLASS I EXPRESSION
Title (en)
METHODS OF ASSESSING MHC CLASS I EXPRESSION AND PROTEINS CAPABLE OF MODULATING CLASS I EXPRESSION
Title (de)
VERFAHREN ZUR BEWERKUNG VON KLASSE I-HAUPTHISTOKOMPATIBILITATS-KOMPLEX-EXPRESSION UND KLASSE-1-EXPRESSION-MODULIERENDE PROTEINE
Title (fr)
PROCEDE D'EVALUATION DE L'EXPRESSION DU COMPLEXE MAJEUR D'HISTOCOMPATIBILITE DANS LA CLASSE I ET PROTEINES CAPABLES DE MODULER L'EXPRESSION EN CLASSE I
Publication
Application
Priority
- US 9613715 W 19960821
- US 50352595 A 19950821
Abstract (en)
[origin: WO9707404A1] The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules. In addition, this invention relates to nucleic acid and amino acid sequences for proteins capable of modulating MHC Class I expression.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/00 (2006.01); A61K 48/00 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); C07K 14/47 (2006.01); C07K 14/74 (2006.01); C07K 16/18 (2006.01); C12N 15/00 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/26 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 37/00 (2017.12); A61P 37/06 (2017.12); C07K 14/4702 (2013.01); C07K 14/4713 (2013.01); C07K 14/70539 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6897 (2013.01); G01N 33/68 (2013.01)
Citation (search report)
See references of WO 9707404A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9707404 A1 19970227; AU 6860096 A 19970312; AU 726441 B2 20001109; CA 2229938 A1 19970227; EP 0880701 A1 19981202; JP H11513115 A 19991109
DOCDB simple family (application)
US 9613715 W 19960821; AU 6860096 A 19960821; CA 2229938 A 19960821; EP 96929056 A 19960821; JP 50957697 A 19960821