EP 0885196 A1 19981223 - CHINOLINE-2-(1H)-ONES
Title (en)
CHINOLINE-2-(1H)-ONES
Title (de)
CHINOLIN-2-(1H)-ONE
Title (fr)
QUINOLEIN-2-(1H)-ONES
Publication
Application
Priority
- DE 19601782 A 19960119
- EP 9700084 W 19970110
Abstract (en)
[origin: US6028080A] PCT No. PCT/EP97/00084 Sec. 371 Date Jul. 17, 1998 Sec. 102(e) Date Jul. 17, 1998 PCT Filed Jan. 10, 1997 PCT Pub. No. WO97/26244 PCT Pub. Date Jul. 24, 1997The invention relates to quinoline-2-(1H)-one derivatives of the general formula I in which R1, R2 and R3 are in each case independently of one another H, Hal, A or OA; R4 is H, -(CH2)m-NR6R7; R5 is H, -(CH2)n-NR6R7; R6 is H, A or, together with R7, -(CH2)4- or -(CH2)5-; R7 is H, A or -(CH2)m- with a bond to the same ring or adjacent ring B or D or, together with R6, -(CH2)4- or -(CH2)5-; X is -CHR5-, -NR5-, -O-, -S-; A is alkyl having 1-6 C atoms; Hal is F, Cl, Br or I; m is 1-3 and n is 0-3, where at least one of the two radicals R4 or R5 has the meaning -(CH2)m-NR6R7 or -(CH2)n-NR6R7, their enantiomers, stereoisomers, salts and solvates. Such compounds are useful for the treatment of neurodegenerative diseases.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/47 (2006.01); A61K 31/4704 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61P 25/28 (2006.01); C07D 215/22 (2006.01); C07D 401/10 (2006.01)
CPC (source: EP KR US)
A61P 25/28 (2017.12 - EP); C07D 215/12 (2013.01 - KR); C07D 215/18 (2013.01 - KR); C07D 215/20 (2013.01 - KR); C07D 215/22 (2013.01 - EP KR US); C07D 217/24 (2013.01 - KR); C07D 401/10 (2013.01 - EP KR US)
Citation (search report)
See references of WO 9726244A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
US 6028080 A 20000222; AR 005646 A1 19990714; AU 1311297 A 19970811; AU 716230 B2 20000224; BR 9707027 A 19990720; CA 2243474 A1 19970724; CA 2243474 C 20091027; CN 1211974 A 19990324; CZ 224098 A3 19981014; DE 19601782 A1 19970724; EP 0885196 A1 19981223; HU P9900563 A2 19990628; HU P9900563 A3 20000228; JP 2000503308 A 20000321; KR 19990077308 A 19991025; MX 9805700 A 19981129; NO 983333 D0 19980717; NO 983333 L 19980918; PL 327829 A1 19990104; SK 93198 A3 19990111; WO 9726244 A1 19970724; ZA 97364 B 19970722
DOCDB simple family (application)
US 10183798 A 19980717; AR P970100184 A 19970117; AU 1311297 A 19970110; BR 9707027 A 19970110; CA 2243474 A 19970110; CN 97192395 A 19970110; CZ 224098 A 19970110; DE 19601782 A 19960119; EP 9700084 W 19970110; EP 97900586 A 19970110; HU P9900563 A 19970110; JP 52565697 A 19970110; KR 19980705454 A 19980716; MX 9805700 A 19980715; NO 983333 A 19980717; PL 32782997 A 19970110; SK 93198 A 19970110; ZA 97364 A 19970116