Global Patent Index - EP 0885243 A4

EP 0885243 A4 2002-11-20 - CRYSTAL STRUCTURE OF APOPAIN AND USES THEREOF

Title (en)

CRYSTAL STRUCTURE OF APOPAIN AND USES THEREOF

Title (de)

KRISTALLSTRUKTUR VON APOPAIN UND DEREN ANWENDUNGEN

Title (fr)

STRUCTURE CRISTALLINE D'APOPAINE ET SON UTILISATION

Publication

EP 0885243 A4 (EN)

Application

EP 97907690 A

Priority

  • GB 9607206 A
  • US 9702578 W
  • US 1214896 P

Abstract (en)

[origin: WO9731018A1] The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.

IPC 1-7 (main, further and additional classification)

C07K 14/00

IPC 8 full level (invention and additional information)

C12N 15/00 (2006.01); C07K 5/113 (2006.01); C07K 14/47 (2006.01); C12N 1/21 (2006.01); C12N 9/64 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01)

CPC (invention and additional information)

C12N 9/6475 (2013.01); C07K 5/1021 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [Y] WO 9535367 A1 19951228 - VERTEX PHARMA [US]
  • [Y] FERNANDES-ALNEMRI T ET AL: "CPP32, A NOVEL HUMAN APOPTOTIC PROTEIN WITH HOMOLOGY TO CAENORHABDITIS ELEGANS CELL DEATH PROTEIN CED-3 AND MAMMALIAN INTERLEUKIN-1BETA-CONVERTING ENZYME", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 49, 9 December 1994 (1994-12-09), pages 30761 - 30764, XP000616157, ISSN: 0021-9258
  • [Y] WALKER N P C ET AL: "CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE INTERLEUKIN-1BETA- CONVERTING ENZYME: A (P20/P10)2 HOMODIMER", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 78, 29 July 1994 (1994-07-29), pages 343 - 352, XP002050334, ISSN: 0092-8674
  • [Y] WILSON K P ET AL: "STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 370, no. 6487, 28 July 1994 (1994-07-28), pages 270 - 275, XP002054972, ISSN: 0028-0836
  • [Y] MCPHERSON A ET AL: "THE SCIENCE OF MACROMOLECULAR CRYSTALLIZATION", STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, vol. 3, 1995, pages 759 - 768, XP001013101, ISSN: 0969-2126
  • See also references of WO 9731018A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9731018 A1 19970828; CA 2247068 A1 19970828; EP 0885243 A1 19981223; EP 0885243 A4 20021120; JP 2000505457 A 20000509

INPADOC legal status


2004-06-09 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20031119

2003-08-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030708

2002-11-20 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20021004

2002-11-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2002-05-15 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: MERCK & CO., INC.

2002-05-15 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: MERCK FROSST CANADA & CO.

1998-12-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19980923

1998-12-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE