Global Patent Index - EP 0885243 A4

EP 0885243 A4 20021120 - CRYSTAL STRUCTURE OF APOPAIN AND USES THEREOF

Title (en)

CRYSTAL STRUCTURE OF APOPAIN AND USES THEREOF

Title (de)

KRISTALLSTRUKTUR VON APOPAIN UND DEREN ANWENDUNGEN

Title (fr)

STRUCTURE CRISTALLINE D'APOPAINE ET SON UTILISATION

Publication

EP 0885243 A4 20021120 (EN)

Application

EP 97907690 A 19970219

Priority

  • GB 9607206 A 19960404
  • US 9702578 W 19970219
  • US 1214896 P 19960223

Abstract (en)

[origin: WO9731018A1] The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.

IPC 1-7

C07K 14/00

IPC 8 full level

C07K 5/113 (2006.01); C07K 14/47 (2006.01); C12N 1/21 (2006.01); C12N 9/64 (2006.01); C12N 15/00 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP)

C07K 5/1021 (2013.01); C12N 9/6475 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [Y] WO 9535367 A1 19951228 - VERTEX PHARMA [US]
  • [Y] FERNANDES-ALNEMRI T ET AL: "CPP32, A NOVEL HUMAN APOPTOTIC PROTEIN WITH HOMOLOGY TO CAENORHABDITIS ELEGANS CELL DEATH PROTEIN CED-3 AND MAMMALIAN INTERLEUKIN-1BETA-CONVERTING ENZYME", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 49, 9 December 1994 (1994-12-09), pages 30761 - 30764, XP000616157, ISSN: 0021-9258
  • [Y] WALKER N P C ET AL: "CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE INTERLEUKIN-1BETA- CONVERTING ENZYME: A (P20/P10)2 HOMODIMER", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 78, 29 July 1994 (1994-07-29), pages 343 - 352, XP002050334, ISSN: 0092-8674
  • [Y] WILSON K P ET AL: "STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 370, no. 6487, 28 July 1994 (1994-07-28), pages 270 - 275, XP002054972, ISSN: 0028-0836
  • [Y] MCPHERSON A ET AL: "THE SCIENCE OF MACROMOLECULAR CRYSTALLIZATION", STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, vol. 3, 1995, pages 759 - 768, XP001013101, ISSN: 0969-2126
  • See references of WO 9731018A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9731018 A1 19970828; CA 2247068 A1 19970828; EP 0885243 A1 19981223; EP 0885243 A4 20021120; JP 2000505457 A 20000509

DOCDB simple family (application)

US 9702578 W 19970219; CA 2247068 A 19970219; EP 97907690 A 19970219; JP 53028597 A 19970219