EP 0888344 A1 19990107 - SPIROCYCLE INTEGRIN INHIBITORS
Title (en)
SPIROCYCLE INTEGRIN INHIBITORS
Title (de)
SPIROCYCLE ALS INTEGRIN INHIBITOREN
Title (fr)
INHIBITEURS DE L'INTEGRINE SPIROCYCLE
Publication
Application
Priority
- US 9704567 W 19970317
- US 1353996 P 19960315
- US 64689696 A 19960508
- US 81658097 A 19970314
Abstract (en)
[origin: WO9733887A1] This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3-[[[8-(2-pyridinylaminomethyl)-]-1-oxa-2-azaspiro-[4,5]-dec-2-en-3-yl]carbonylamino]propionic acid, which are useful as antagonists of the alpha v beta 3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
IPC 1-7
IPC 8 full level
A61K 31/416 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/423 (2006.01); A61K 31/424 (2006.01); A61K 31/4245 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/438 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/506 (2006.01); A61K 31/55 (2006.01); A61P 3/14 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 19/10 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07D 231/54 (2006.01); C07D 261/20 (2006.01); C07D 271/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 498/10 (2006.01); C07D 519/00 (2006.01)
CPC (source: EP)
A61P 3/14 (2017.12); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 19/10 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 35/04 (2017.12); A61P 43/00 (2017.12); C07D 261/20 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)
Citation (search report)
See references of WO 9733887A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9733887 A1 19970918; AU 2421797 A 19971001; CA 2249733 A1 19970918; EP 0888344 A1 19990107; JP 2001527513 A 20011225
DOCDB simple family (application)
US 9704567 W 19970317; AU 2421797 A 19970317; CA 2249733 A 19970317; EP 97919892 A 19970317; JP 53292497 A 19970317